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Development of an Enantioselective Allylic Alkylation of Acyclic α‐Fluoro‐β‐ketoesters for Asymmetric Synthesis of 3‐Fluoropiperidines

The first useful enantioselective Pd‐catalyzed asymmetric allylic alkylation of α‐fluoro‐β‐ketoesters has been achieved using the Trost family of chiral ligands yielding products in up to 92 % ee. This work provides new insights regarding the typically modest selectivities associated with acyclic α‐...

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Detalles Bibliográficos
Autores principales: Han, Jiaxin, Hoteite, Larry, Harrity, Joseph P. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804466/
https://www.ncbi.nlm.nih.gov/pubmed/35815542
http://dx.doi.org/10.1002/chem.202201595

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