Cargando…

Phase 1/1b Studies of UCB0599, an Oral Inhibitor of α‐Synuclein Misfolding, Including a Randomized Study in Parkinson's Disease

BACKGROUND: Parkinson's disease (PD) and its progression are thought to be caused and driven by misfolding of α‐synuclein (ASYN). UCB0599 is an oral, small‐molecule inhibitor of ASYN misfolding, aimed at slowing disease progression. OBJECTIVE: The aim was to investigate safety/tolerability and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smit, Johan Willem, Basile, Peter, Prato, Maria Key, Detalle, Laurent, Mathy, François‐Xavier, Schmidt, Astrid, Lalla, Marianna, Germani, Massimiliano, Domange, Coralie, Biere, Anja‐Leona, Bani, Massimo, Carson, Stan, Genius, Just
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Regular Issue Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804489/ https://www.ncbi.nlm.nih.gov/pubmed/35959805 http://dx.doi.org/10.1002/mds.29170

Ejemplares similares

High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599
por: Schwarz, Thomas C., et al.
Publicado: (2023)

In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease
por: Price, Diana L., et al.
Publicado: (2023)

Import and Export of Misfolded α-Synuclein
por: Rodriguez, Lilia, et al.
Publicado: (2018)

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein
por: Krasnoslobodtsev, Alexey V., et al.
Publicado: (2012)

The Role of Lipids in the Initiation of α-Synuclein Misfolding
por: Kiechle, Martin, et al.
Publicado: (2020)

Synucleins: New Data on Misfolding, Aggregation and Role in Diseases
por: Surguchov, Andrei, et al.
Publicado: (2022)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

UCB HCT in FLT3+ AML
por: Ustun, Celalettin, et al.
Publicado: (2017)

The α-Synuclein Monomer May Have Different Misfolding Mechanisms in the Induction of α-Synuclein Fibrils with Different Polymorphs
por: Zhao, Nannan, et al.
Publicado: (2023)

Partial volume correction analysis for (11)C-UCB-J PET studies of Alzheimer’s disease
por: Lu, Yihuan, et al.
Publicado: (2021)

Feasibility of imaging synaptic density in the human spinal cord using [(11)C]UCB-J PET
por: Rossano, Samantha, et al.
Publicado: (2022)

Isoextraction Studies of Partition of UCB Between Chloroform and Aqueous Solution
por: Hahm, Joon Soo, et al.
Publicado: (1987)

Reducing the osteoporosis treatment gap: an interview with UCB's Pascale Richetta
por: Richetta, Pascale
Publicado: (2017)

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
por: Pace, Michael C., et al.
Publicado: (2018)

Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification
por: Jung, Byung Chul, et al.
Publicado: (2017)

Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease
por: Jakova, Elisabet, et al.
Publicado: (2022)

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
por: Panicker, Nikhil, et al.
Publicado: (2019)

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells
por: Ugalde, Cathryn L., et al.
Publicado: (2020)

Identifying brain networks in synaptic density PET ((11)C-UCB-J) with independent component analysis
por: Fang, Xiaotian T., et al.
Publicado: (2021)

Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand (11)C-UCB-J
por: Bini, Jason, et al.
Publicado: (2020)

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)
por: Herva, Maria Eugenia, et al.
Publicado: (2014)

Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC
por: Sano, Kazunori, et al.
Publicado: (2017)

Potential of [(11)C]UCB-J as a PET tracer for islets of Langerhans
por: Puuvuori, Emmi, et al.
Publicado: (2021)

Principal component analysis of synaptic density measured with [(11)C]UCB-J PET in early Alzheimer’s disease
por: O'Dell, Ryan S., et al.
Publicado: (2023)

Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [(11)C]UCB‐J
por: Mecca, Adam P., et al.
Publicado: (2022)

Baseline concentration of misfolded α‐synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease
por: Ning, H., et al.
Publicado: (2018)

Improved synthesis of SV2A targeting radiotracer [(11)C]UCB-J
por: Rokka, Johanna, et al.
Publicado: (2019)

Validation and noninvasive kinetic modeling of [(11)C]UCB-J PET imaging in mice
por: Bertoglio, Daniele, et al.
Publicado: (2019)

The pharmacokinetics of [(18)F]UCB-H revisited in the healthy non-human primate brain
por: Goutal, Sébastien, et al.
Publicado: (2021)

(11)C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies
por: Nicastro, Nicolas, et al.
Publicado: (2020)

Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and (11)C-UCB-J PET study
por: Fang, Xiaotian T., et al.
Publicado: (2023)

α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
por: Dilsizoglu Senol, Aysegul, et al.
Publicado: (2021)

Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis
por: Peña-Bautista, Carmen, et al.
Publicado: (2023)

Preclinical radiation dosimetry for the novel SV2A radiotracer [(18)F]UCB-H
por: Bretin, Florian, et al.
Publicado: (2013)

Automated radiosynthesis of [(11)C]UCB‐J for imaging synaptic density by positron emission tomography
por: Milicevic Sephton, Selena, et al.
Publicado: (2020)

Validation and test–retest repeatability performance of parametric methods for [(11)C]UCB-J PET
por: Tuncel, Hayel, et al.
Publicado: (2022)

Treatment of Radiation Bone Injury with Transplanted hUCB-MSCs via Wnt/β-Catenin
por: Zhang, Yufeng, et al.
Publicado: (2021)

Synaptic Loss in Frontotemporal Dementia Revealed by [ (11)C]UCB‐J Positron Emission Tomography
por: Malpetti, Maura, et al.
Publicado: (2022)

Role of Protein Misfolding and Proteostasis Deficiency in Protein Misfolding Diseases and Aging
por: Cuanalo-Contreras, Karina, et al.
Publicado: (2013)

The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease
por: Price, Diana L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6p5qvs5ucc3vg90j68t4q7lr1d