RPRM deletion preserves hematopoietic regeneration by promoting EGFR‐dependent DNA repair and hematopoietic stem cell proliferation post ionizing radiation

Reprimo (RPRM), a target gene of p53, is a known tumor suppressor. DNA damage induces RPRM, which triggers p53‐dependent G2 arrest by inhibiting cyclin B1/Cdc2 complex activation and promotes DNA damage‐induced apoptosis. RPRM negatively regulates ataxia‐telangiectasia mutated by promoting its nucle...

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Detalles Bibliográficos
Autores principales: Li, Zixuan, Zhou, Zhou, Tian, Shuaiyu, Zhang, Kailu, An, Gangli, Zhang, Yarui, Ma, Renyuxue, Sheng, Binjie, Wang, Tian, Yang, Hongying, Yang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804513/
https://www.ncbi.nlm.nih.gov/pubmed/36041213
http://dx.doi.org/10.1002/cbin.11900

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