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A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites

A molecular system comprising a cationic zinc complex and an amino acid‐derived ambident ligand having phosphate and carboxylate binding sites undergoes a series of rearrangements in which the metal cation migrates autonomously from one site to another. The location of the metal is identified by the...

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Autores principales: Wootten, Matthew M., Tshepelevitsh, Sofja, Leito, Ivo, Clayden, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804598/
https://www.ncbi.nlm.nih.gov/pubmed/35880579
http://dx.doi.org/10.1002/chem.202202247
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author Wootten, Matthew M.
Tshepelevitsh, Sofja
Leito, Ivo
Clayden, Jonathan
author_facet Wootten, Matthew M.
Tshepelevitsh, Sofja
Leito, Ivo
Clayden, Jonathan
author_sort Wootten, Matthew M.
collection PubMed
description A molecular system comprising a cationic zinc complex and an amino acid‐derived ambident ligand having phosphate and carboxylate binding sites undergoes a series of rearrangements in which the metal cation migrates autonomously from one site to another. The location of the metal is identified by the circular dichroism spectrum of a ligated bis(2‐quinolylmethyl)‐(2‐pyridylmethyl)amine (BQPA) chromophore, which takes a characteristic shape at each binding site. Migration is fuelled by the decomposition of trichloroacetic acid to CO(2) and CHCl(3), which progressively neutralises the acidity of the system as a function of time, revealing in sequence binding sites of increasing basicity. The migration rate responds to control by variation of the temperature, water content and triethylamine concentration, while an excess of fuel controls the duration of an induction period before the migration event.
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spelling pubmed-98045982023-01-03 A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites Wootten, Matthew M. Tshepelevitsh, Sofja Leito, Ivo Clayden, Jonathan Chemistry Research Articles A molecular system comprising a cationic zinc complex and an amino acid‐derived ambident ligand having phosphate and carboxylate binding sites undergoes a series of rearrangements in which the metal cation migrates autonomously from one site to another. The location of the metal is identified by the circular dichroism spectrum of a ligated bis(2‐quinolylmethyl)‐(2‐pyridylmethyl)amine (BQPA) chromophore, which takes a characteristic shape at each binding site. Migration is fuelled by the decomposition of trichloroacetic acid to CO(2) and CHCl(3), which progressively neutralises the acidity of the system as a function of time, revealing in sequence binding sites of increasing basicity. The migration rate responds to control by variation of the temperature, water content and triethylamine concentration, while an excess of fuel controls the duration of an induction period before the migration event. John Wiley and Sons Inc. 2022-08-17 2022-10-21 /pmc/articles/PMC9804598/ /pubmed/35880579 http://dx.doi.org/10.1002/chem.202202247 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Wootten, Matthew M.
Tshepelevitsh, Sofja
Leito, Ivo
Clayden, Jonathan
A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites
title A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites
title_full A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites
title_fullStr A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites
title_full_unstemmed A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites
title_short A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of Zn(2+) Between Alternative Binding Sites
title_sort chemically fuelled molecular automaton displaying programmed migration of zn(2+) between alternative binding sites
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804598/
https://www.ncbi.nlm.nih.gov/pubmed/35880579
http://dx.doi.org/10.1002/chem.202202247
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