Transcriptional signature of TP53 biallelic inactivation identifies a group of multiple myeloma patients without this genetic condition but with dismal outcome

Biallelic inactivation of TP53 has been included in the definition of double‐hit (DH) multiple myeloma (MM), which entails an ominous prognosis. However, this condition, or even the presence of high‐risk cytogenetic abnormalities, cannot accurately capture the 15%–20% of the MM population with a med...

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Detalles Bibliográficos
Autores principales: De Ramón, Cristina, Rojas, Elizabeta A., Cardona‐Benavides, Ignacio J., Mateos, Maria‐Victoria, Corchete, Luis A., Gutiérrez, Norma C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Haematological Malignancy–Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804640/
https://www.ncbi.nlm.nih.gov/pubmed/35983648
http://dx.doi.org/10.1111/bjh.18410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804640/
https://www.ncbi.nlm.nih.gov/pubmed/35983648
http://dx.doi.org/10.1111/bjh.18410

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