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Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study

BACKGROUND: Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD). OBJECTIVE: The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐dominant...

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Autores principales: Golfrè Andreasi, Nico, Cilia, Roberto, Romito, Luigi Michele, Bonvegna, Salvatore, Straccia, Giulia, Elia, Antonio Emanuele, Novelli, Alessio, Messina, Giuseppe, Tringali, Giovanni, Levi, Vincenzo, Devigili, Grazia, Rinaldo, Sara, Gasparini, Valentina, Grisoli, Marina, Stanziano, Mario, Ghielmetti, Francesco, Prioni, Sara, Bocchi, Elisa, Amami, Paolo, Piacentini, Sylvie Hélène Marie Jeanne, Ciceri, Elisa Francesca Maria, Bruzzone, Maria Grazia, Eleopra, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804690/
https://www.ncbi.nlm.nih.gov/pubmed/36036203
http://dx.doi.org/10.1002/mds.29200
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author Golfrè Andreasi, Nico
Cilia, Roberto
Romito, Luigi Michele
Bonvegna, Salvatore
Straccia, Giulia
Elia, Antonio Emanuele
Novelli, Alessio
Messina, Giuseppe
Tringali, Giovanni
Levi, Vincenzo
Devigili, Grazia
Rinaldo, Sara
Gasparini, Valentina
Grisoli, Marina
Stanziano, Mario
Ghielmetti, Francesco
Prioni, Sara
Bocchi, Elisa
Amami, Paolo
Piacentini, Sylvie Hélène Marie Jeanne
Ciceri, Elisa Francesca Maria
Bruzzone, Maria Grazia
Eleopra, Roberto
author_facet Golfrè Andreasi, Nico
Cilia, Roberto
Romito, Luigi Michele
Bonvegna, Salvatore
Straccia, Giulia
Elia, Antonio Emanuele
Novelli, Alessio
Messina, Giuseppe
Tringali, Giovanni
Levi, Vincenzo
Devigili, Grazia
Rinaldo, Sara
Gasparini, Valentina
Grisoli, Marina
Stanziano, Mario
Ghielmetti, Francesco
Prioni, Sara
Bocchi, Elisa
Amami, Paolo
Piacentini, Sylvie Hélène Marie Jeanne
Ciceri, Elisa Francesca Maria
Bruzzone, Maria Grazia
Eleopra, Roberto
author_sort Golfrè Andreasi, Nico
collection PubMed
description BACKGROUND: Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD). OBJECTIVE: The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy. METHODS: We prospectively enrolled patients with early‐stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD‐FUS) and patients treated with oral dopaminergic therapy (PD‐ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy. RESULTS: We included 10 patients in the PD‐FUS group and 20 patients in the PD‐ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD‐ODT group 6 months after thalamotomy. CONCLUSIONS: In early‐stage tremor‐dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
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spelling pubmed-98046902023-01-06 Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study Golfrè Andreasi, Nico Cilia, Roberto Romito, Luigi Michele Bonvegna, Salvatore Straccia, Giulia Elia, Antonio Emanuele Novelli, Alessio Messina, Giuseppe Tringali, Giovanni Levi, Vincenzo Devigili, Grazia Rinaldo, Sara Gasparini, Valentina Grisoli, Marina Stanziano, Mario Ghielmetti, Francesco Prioni, Sara Bocchi, Elisa Amami, Paolo Piacentini, Sylvie Hélène Marie Jeanne Ciceri, Elisa Francesca Maria Bruzzone, Maria Grazia Eleopra, Roberto Mov Disord Brief Reports BACKGROUND: Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug‐resistant tremor in Parkinson's disease (PD). OBJECTIVE: The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early‐stage tremor‐dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy. METHODS: We prospectively enrolled patients with early‐stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD‐FUS) and patients treated with oral dopaminergic therapy (PD‐ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy. RESULTS: We included 10 patients in the PD‐FUS group and 20 patients in the PD‐ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD‐ODT group 6 months after thalamotomy. CONCLUSIONS: In early‐stage tremor‐dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society John Wiley & Sons, Inc. 2022-08-29 2022-11 /pmc/articles/PMC9804690/ /pubmed/36036203 http://dx.doi.org/10.1002/mds.29200 Text en © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Golfrè Andreasi, Nico
Cilia, Roberto
Romito, Luigi Michele
Bonvegna, Salvatore
Straccia, Giulia
Elia, Antonio Emanuele
Novelli, Alessio
Messina, Giuseppe
Tringali, Giovanni
Levi, Vincenzo
Devigili, Grazia
Rinaldo, Sara
Gasparini, Valentina
Grisoli, Marina
Stanziano, Mario
Ghielmetti, Francesco
Prioni, Sara
Bocchi, Elisa
Amami, Paolo
Piacentini, Sylvie Hélène Marie Jeanne
Ciceri, Elisa Francesca Maria
Bruzzone, Maria Grazia
Eleopra, Roberto
Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study
title Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study
title_full Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study
title_fullStr Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study
title_full_unstemmed Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study
title_short Magnetic Resonance–Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early‐Stage Tremor‐Dominant Parkinson's Disease: A Pilot Study
title_sort magnetic resonance–guided focused ultrasound thalamotomy may spare dopaminergic therapy in early‐stage tremor‐dominant parkinson's disease: a pilot study
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804690/
https://www.ncbi.nlm.nih.gov/pubmed/36036203
http://dx.doi.org/10.1002/mds.29200
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