Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola‐amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola‐amphiphil...

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Detalles Bibliográficos
Autores principales: Zhang, Wenzheng, Dhumal, Dinesh, Zhu, Xiaolei, Ralahy, Brigino, Ellert‐Miklaszewska, Aleksandra, Wu, Jing, Laurini, Erik, Yao, Yi‐Wen, Kao, Chai‐Lin, Iovanna, Juan L., Pricl, Sabrina, Kaminska, Bozena, Xia, Yi, Peng, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804701/
https://www.ncbi.nlm.nih.gov/pubmed/35820051
http://dx.doi.org/10.1002/chem.202201400
Descripción
Sumario:Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola‐amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola‐amphiphilic feature enabled stronger binding to lectin compared to conventional amphiphiles. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, thus allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.

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