Semisynthesis of Homogeneous, Active Granulocyte Colony‐Stimulating Factor Glycoforms

Granulocyte colony stimulating factor (G‐CSF) is a cytokine used to treat neutropenia. Different glycosylated and non‐glycosylated variants of G‐CSF for therapeutic application are currently generated by recombinant expression. Here, we describe our approaches to establish a first semisynthesis stra...

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Detalles Bibliográficos
Autores principales: Kerul, Lukas, Schrems, Maximilian, Schmid, Alanca, Meli, Rajeshwari, Becker, Christian F. W., Bello, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804750/
https://www.ncbi.nlm.nih.gov/pubmed/35853828
http://dx.doi.org/10.1002/anie.202206116

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