Endoplasmic reticulum oxidoreductin 1‐alpha deficiency and activation of protein translation synergistically impair breast tumour resilience

BACKGROUND AND PURPOSE: Endoplasmic reticulum (ER) stress triggers an adaptive response in tumours which fosters cell survival and resilience to stress. Activation of the ER stress response, through its PERK branch, promotes phosphorylation of the α‐subunit of the translation initiation factor eIF2,...

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Detalles Bibliográficos
Autores principales: Varone, Ersilia, Decio, Alessandra, Barbera, Maria Chiara, Bolis, Marco, Di Rito, Laura, Pisati, Federica, Giavazzi, Raffaella, Zito, Ester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804893/
https://www.ncbi.nlm.nih.gov/pubmed/35853086
http://dx.doi.org/10.1111/bph.15927

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