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DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling

We report the density functional theory (DFT) guided discovery of ethynyl‐triazolyl‐phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective bioconjugation. By using Cu(I)‐catalysed azide alkyne cycloaddition (CuAAC) in aqueous buffer, we were able to access a variety of f...

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Detalles Bibliográficos
Autores principales:	Stieger, Christian E., Park, Yerin, de Geus, Mark A. R., Kim, Dongju, Huhn, Christiane, Slenczka, J. Sophia, Ochtrop, Philipp, Müchler, Judith M., Süssmuth, Roderich D., Broichhagen, Johannes, Baik, Mu‐Hyun, Hackenberger, Christian P. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804898/ https://www.ncbi.nlm.nih.gov/pubmed/35792701 http://dx.doi.org/10.1002/anie.202205348

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