Persistent T‐cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID‐19: Results from two Norwegian cohort studies

BACKGROUND: T‐cell activation is associated with an adverse outcome in COVID‐19, but whether T‐cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. OBJECTIVES: To investigate whether T‐cell activation and exhaustion persist and are associated with prolong...

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Detalles Bibliográficos
Autores principales: Trøseid, Marius, Dahl, Tuva B., Holter, Jan C., Kildal, Anders B., Murphy, Sarah L., Yang, Kuan, Quiles‐Jiménez, Ana, Heggelund, Lars, Müller, Karl Erik, Tveita, Anders, Michelsen, Annika E., Bøe, Simen, Holten, Aleksander R., Hoel, Hedda, Mathiessen, Alexander, Aaløkken, Trond M., Fevang, Børre, Granerud, Beathe K., Tonby, Kristian, Henriksen, Katerina N., Lerum, Tøri V., Müller, Fredrik, Skjønsberg, Ole H., Barratt‐Due, Andreas, Dyrhol‐Riise, Anne M., Aukrust, Pål, Halvorsen, Bente, Ueland, Thor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805032/
https://www.ncbi.nlm.nih.gov/pubmed/35982589
http://dx.doi.org/10.1111/joim.13549
Descripción
Sumario:BACKGROUND: T‐cell activation is associated with an adverse outcome in COVID‐19, but whether T‐cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. OBJECTIVES: To investigate whether T‐cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID‐19. METHODS: Plasma and serum from two Norwegian cohorts of hospitalized patients with COVID‐19 (n = 414) were analyzed for soluble (s) markers of T‐cell activation (sCD25) and exhaustion (sTim‐3) during hospitalization and follow‐up. RESULTS: Both markers were strongly associated with acute respiratory failure, but only sTim‐3 was independently associated with 60‐day mortality. Levels of sTim‐3 remained elevated 3 and 12 months after hospitalization and were associated with pulmonary radiological pathology after 3 months. CONCLUSION: Our findings suggest prolonged T‐cell exhaustion is an important immunological sequela, potentially related to long‐term outcomes after severe COVID‐19.

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