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Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides
The photoswitchable motif of azobenzenes is of great importance across the life and materials sciences. This maintains a constant demand for their efficient synthesis, especially that of non‐symmetric derivatives. We disclose here a general strategy for their synthesis through an unprecedented C(sp(...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805057/ https://www.ncbi.nlm.nih.gov/pubmed/35959922 http://dx.doi.org/10.1002/anie.202210907 |
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author | Finck, Lucie Oestreich, Martin |
author_facet | Finck, Lucie Oestreich, Martin |
author_sort | Finck, Lucie |
collection | PubMed |
description | The photoswitchable motif of azobenzenes is of great importance across the life and materials sciences. This maintains a constant demand for their efficient synthesis, especially that of non‐symmetric derivatives. We disclose here a general strategy for their synthesis through an unprecedented C(sp(2))−N(sp(2)) cross‐coupling where functionalized aryl‐substituted diazenes masked with a silyl group are employed as diazenyl pronucleophiles. These equivalents of fragile diazenyl anions couple with a diverse set of (hetero)aryl bromides under palladium catalysis with no loss of dinitrogen. The competing denitrogenative biaryl formation is fully suppressed. The reaction requires only a minimal excess, that is 1.2 equivalents, of the diazenyl component. By this, a broad range of azoarenes decorated with two electron‐rich/deficient aryl groups can be accessed in a predictable way with superb functional‐group tolerance. |
format | Online Article Text |
id | pubmed-9805057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98050572023-01-06 Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides Finck, Lucie Oestreich, Martin Angew Chem Int Ed Engl Communications The photoswitchable motif of azobenzenes is of great importance across the life and materials sciences. This maintains a constant demand for their efficient synthesis, especially that of non‐symmetric derivatives. We disclose here a general strategy for their synthesis through an unprecedented C(sp(2))−N(sp(2)) cross‐coupling where functionalized aryl‐substituted diazenes masked with a silyl group are employed as diazenyl pronucleophiles. These equivalents of fragile diazenyl anions couple with a diverse set of (hetero)aryl bromides under palladium catalysis with no loss of dinitrogen. The competing denitrogenative biaryl formation is fully suppressed. The reaction requires only a minimal excess, that is 1.2 equivalents, of the diazenyl component. By this, a broad range of azoarenes decorated with two electron‐rich/deficient aryl groups can be accessed in a predictable way with superb functional‐group tolerance. John Wiley and Sons Inc. 2022-08-29 2022-10-04 /pmc/articles/PMC9805057/ /pubmed/35959922 http://dx.doi.org/10.1002/anie.202210907 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Communications Finck, Lucie Oestreich, Martin Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides |
title | Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides |
title_full | Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides |
title_fullStr | Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides |
title_full_unstemmed | Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides |
title_short | Synthesis of Non‐Symmetric Azoarenes by Palladium‐Catalyzed Cross‐Coupling of Silicon‐Masked Diazenyl Anions and (Hetero)Aryl Halides |
title_sort | synthesis of non‐symmetric azoarenes by palladium‐catalyzed cross‐coupling of silicon‐masked diazenyl anions and (hetero)aryl halides |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805057/ https://www.ncbi.nlm.nih.gov/pubmed/35959922 http://dx.doi.org/10.1002/anie.202210907 |
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