Biocompatible and Selective Generation of Bicyclic Peptides

Bicyclic peptides possess superior properties for drug discovery; however, their chemical synthesis is not straightforward and often neither biocompatible nor fully orthogonal to all canonical amino acids. The selective reaction between 1,2‐aminothiols and 2,6‐dicyanopyridine allows direct access to...

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Detalles Bibliográficos
Autores principales: Ullrich, Sven, George, Josemon, Coram, Alexandra E., Morewood, Richard, Nitsche, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805059/
https://www.ncbi.nlm.nih.gov/pubmed/35852030
http://dx.doi.org/10.1002/anie.202208400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805059/
https://www.ncbi.nlm.nih.gov/pubmed/35852030
http://dx.doi.org/10.1002/anie.202208400

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