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Biocompatible and Selective Generation of Bicyclic Peptides
Bicyclic peptides possess superior properties for drug discovery; however, their chemical synthesis is not straightforward and often neither biocompatible nor fully orthogonal to all canonical amino acids. The selective reaction between 1,2‐aminothiols and 2,6‐dicyanopyridine allows direct access to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805059/ https://www.ncbi.nlm.nih.gov/pubmed/35852030 http://dx.doi.org/10.1002/anie.202208400 |