Long‐term normothermic perfusion of human livers for longer than 12 days

In this case report, we preserved human livers for up to 13 days under normothermic conditions using a modified commercial perfusion system. Two whole livers were split into two left lateral segment grafts and two extended right grafts without interruption to blood flow and then perfused on separate...

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Detalles Bibliográficos
Autores principales: Lau, Ngee‐Soon, Ly, Mark, Dennis, Claude, Liu, Ken, Kench, James, Crawford, Michael, Pulitano, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805080/
https://www.ncbi.nlm.nih.gov/pubmed/35929443
http://dx.doi.org/10.1111/aor.14372
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author Lau, Ngee‐Soon
Ly, Mark
Dennis, Claude
Liu, Ken
Kench, James
Crawford, Michael
Pulitano, Carlo
author_facet Lau, Ngee‐Soon
Ly, Mark
Dennis, Claude
Liu, Ken
Kench, James
Crawford, Michael
Pulitano, Carlo
author_sort Lau, Ngee‐Soon
collection PubMed
description In this case report, we preserved human livers for up to 13 days under normothermic conditions using a modified commercial perfusion system. Two whole livers were split into two left lateral segment grafts and two extended right grafts without interruption to blood flow and then perfused on separate machines. Not only does this provide the basis for a meaningful study of liver function in the long term, but this could also facilitate the development of a model of ex situ liver regeneration.[Image: see text]
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spelling pubmed-98050802023-01-06 Long‐term normothermic perfusion of human livers for longer than 12 days Lau, Ngee‐Soon Ly, Mark Dennis, Claude Liu, Ken Kench, James Crawford, Michael Pulitano, Carlo Artif Organs Case Report In this case report, we preserved human livers for up to 13 days under normothermic conditions using a modified commercial perfusion system. Two whole livers were split into two left lateral segment grafts and two extended right grafts without interruption to blood flow and then perfused on separate machines. Not only does this provide the basis for a meaningful study of liver function in the long term, but this could also facilitate the development of a model of ex situ liver regeneration.[Image: see text] John Wiley and Sons Inc. 2022-08-05 2022-12 /pmc/articles/PMC9805080/ /pubmed/35929443 http://dx.doi.org/10.1111/aor.14372 Text en © 2022 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Lau, Ngee‐Soon
Ly, Mark
Dennis, Claude
Liu, Ken
Kench, James
Crawford, Michael
Pulitano, Carlo
Long‐term normothermic perfusion of human livers for longer than 12 days
title Long‐term normothermic perfusion of human livers for longer than 12 days
title_full Long‐term normothermic perfusion of human livers for longer than 12 days
title_fullStr Long‐term normothermic perfusion of human livers for longer than 12 days
title_full_unstemmed Long‐term normothermic perfusion of human livers for longer than 12 days
title_short Long‐term normothermic perfusion of human livers for longer than 12 days
title_sort long‐term normothermic perfusion of human livers for longer than 12 days
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805080/
https://www.ncbi.nlm.nih.gov/pubmed/35929443
http://dx.doi.org/10.1111/aor.14372
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