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SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

BACKGROUND: The gene encoding the E3 ubiquitin ligase substrate-binding adapter Speckle-type BTB/POZ protein (SPOP) is frequently mutated in prostate cancer (PCa) and endometrial cancer (EC); however, the molecular mechanisms underlying the contribution of SPOP mutations to tumorigenesis remain poor...

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Detalles Bibliográficos
Autores principales:	Feng, Kai, Shi, Qing, Jiao, Dongyue, Chen, Yingji, Yang, Wanqi, Su, Ke, Wang, Yalan, Huang, Yan, Zhang, Pingzhao, Li, Yao, Wang, Chenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805134/ https://www.ncbi.nlm.nih.gov/pubmed/36585710 http://dx.doi.org/10.1186/s13578-022-00950-z

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