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Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo

Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These materials are thought to increase therapeutic outcome and improve current cancer management. Due to their size, nanomedicines target tumors passively...

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Autores principales: Poulie, Christian B. M., Sporer, Emanuel, Hvass, Lars, Jørgensen, Jesper T., Kempen, Paul J., Lopes van den Broek, Sara I., Shalgunov, Vladimir, Kjaer, Andreas, Jensen, Andreas I., Herth, Matthias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805177/
https://www.ncbi.nlm.nih.gov/pubmed/35851967
http://dx.doi.org/10.1002/chem.202201847
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author Poulie, Christian B. M.
Sporer, Emanuel
Hvass, Lars
Jørgensen, Jesper T.
Kempen, Paul J.
Lopes van den Broek, Sara I.
Shalgunov, Vladimir
Kjaer, Andreas
Jensen, Andreas I.
Herth, Matthias M.
author_facet Poulie, Christian B. M.
Sporer, Emanuel
Hvass, Lars
Jørgensen, Jesper T.
Kempen, Paul J.
Lopes van den Broek, Sara I.
Shalgunov, Vladimir
Kjaer, Andreas
Jensen, Andreas I.
Herth, Matthias M.
author_sort Poulie, Christian B. M.
collection PubMed
description Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These materials are thought to increase therapeutic outcome and improve current cancer management. Due to their size, nanomedicines target tumors passively. Thus, they can be used for drug delivery purposes. Bioorthogonal chemistry allows for a pretargeting approach. Higher target‐to‐background drug accumulation ratios can be achieved. Pretargeting can also be used to induce internalization processes or trigger controlled drug release. Colloidal gold nanoparticles (AuNPs) have attracted widespread interest as drug delivery vectors within the last decades. Here, we demonstrate for the first time the possibility to successfully ligate AuNPs in vivo to pretargeted monoclonal antibodies. We believe that this possibility will facilitate the development of AuNPs for clinical use and ultimately, improve state‐of‐the‐art patient care.
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spelling pubmed-98051772023-01-06 Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo Poulie, Christian B. M. Sporer, Emanuel Hvass, Lars Jørgensen, Jesper T. Kempen, Paul J. Lopes van den Broek, Sara I. Shalgunov, Vladimir Kjaer, Andreas Jensen, Andreas I. Herth, Matthias M. Chemistry Research Articles Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These materials are thought to increase therapeutic outcome and improve current cancer management. Due to their size, nanomedicines target tumors passively. Thus, they can be used for drug delivery purposes. Bioorthogonal chemistry allows for a pretargeting approach. Higher target‐to‐background drug accumulation ratios can be achieved. Pretargeting can also be used to induce internalization processes or trigger controlled drug release. Colloidal gold nanoparticles (AuNPs) have attracted widespread interest as drug delivery vectors within the last decades. Here, we demonstrate for the first time the possibility to successfully ligate AuNPs in vivo to pretargeted monoclonal antibodies. We believe that this possibility will facilitate the development of AuNPs for clinical use and ultimately, improve state‐of‐the‐art patient care. John Wiley and Sons Inc. 2022-09-01 2022-11-02 /pmc/articles/PMC9805177/ /pubmed/35851967 http://dx.doi.org/10.1002/chem.202201847 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Poulie, Christian B. M.
Sporer, Emanuel
Hvass, Lars
Jørgensen, Jesper T.
Kempen, Paul J.
Lopes van den Broek, Sara I.
Shalgunov, Vladimir
Kjaer, Andreas
Jensen, Andreas I.
Herth, Matthias M.
Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
title Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
title_full Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
title_fullStr Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
title_full_unstemmed Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
title_short Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
title_sort bioorthogonal click of colloidal gold nanoparticles to antibodies in vivo
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805177/
https://www.ncbi.nlm.nih.gov/pubmed/35851967
http://dx.doi.org/10.1002/chem.202201847
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