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Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells
Microplastics (MPs) represent a worldwide emerging relevant concern toward human and environmental health due to their intentional or unintentional release. Human exposure to MPs by inhalation is predicted to be among the most hazardous. MPs include both engineered, or primary MPs, and secondary MPs...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805234/ https://www.ncbi.nlm.nih.gov/pubmed/35929361 http://dx.doi.org/10.1002/jat.4372 |
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author | Bengalli, Rossella Zerboni, Alessandra Bonfanti, Patrizia Saibene, Melissa Mehn, Dora Cella, Claudia Ponti, Jessica La Spina, Rita Mantecca, Paride |
author_facet | Bengalli, Rossella Zerboni, Alessandra Bonfanti, Patrizia Saibene, Melissa Mehn, Dora Cella, Claudia Ponti, Jessica La Spina, Rita Mantecca, Paride |
author_sort | Bengalli, Rossella |
collection | PubMed |
description | Microplastics (MPs) represent a worldwide emerging relevant concern toward human and environmental health due to their intentional or unintentional release. Human exposure to MPs by inhalation is predicted to be among the most hazardous. MPs include both engineered, or primary MPs, and secondary MPs, materials obtained by fragmentation from any plastic good. The major part of the environmental MPs is constituted by the second ones that are irregular in size, shape and composition. These features make the study of the biological impact of heterogenous MPs of extremely high relevance to better estimate the real toxicological hazards of these materials on human and environmental organisms. The smallest fractions of plastic granules, relying on the micron‐sized scale, can be considered as the most abundant component of the environmental MPs, and for this reason, they are typically used to perform toxicity tests using in vitro systems representative of an inhalation exposure scenario. In the present work, MPs obtained from industrial treatment of waste plastics (wMPs < 50 μm) were investigated, and after the physico‐chemical characterization, the cytotoxic, inflammatory and genotoxic responses, as well as the modality of wMPs interactions with alveolar lung cells, were determined. Obtained results indicated that, at high concentrations (100 μg/ml) and prolonged exposure time (48 h), wMPs affect biological responses by inducing inflammation and genotoxicity, as a result of the cell–wMP interactions, also including the uptake of the smaller particles. |
format | Online Article Text |
id | pubmed-9805234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98052342023-01-06 Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells Bengalli, Rossella Zerboni, Alessandra Bonfanti, Patrizia Saibene, Melissa Mehn, Dora Cella, Claudia Ponti, Jessica La Spina, Rita Mantecca, Paride J Appl Toxicol Research Articles Microplastics (MPs) represent a worldwide emerging relevant concern toward human and environmental health due to their intentional or unintentional release. Human exposure to MPs by inhalation is predicted to be among the most hazardous. MPs include both engineered, or primary MPs, and secondary MPs, materials obtained by fragmentation from any plastic good. The major part of the environmental MPs is constituted by the second ones that are irregular in size, shape and composition. These features make the study of the biological impact of heterogenous MPs of extremely high relevance to better estimate the real toxicological hazards of these materials on human and environmental organisms. The smallest fractions of plastic granules, relying on the micron‐sized scale, can be considered as the most abundant component of the environmental MPs, and for this reason, they are typically used to perform toxicity tests using in vitro systems representative of an inhalation exposure scenario. In the present work, MPs obtained from industrial treatment of waste plastics (wMPs < 50 μm) were investigated, and after the physico‐chemical characterization, the cytotoxic, inflammatory and genotoxic responses, as well as the modality of wMPs interactions with alveolar lung cells, were determined. Obtained results indicated that, at high concentrations (100 μg/ml) and prolonged exposure time (48 h), wMPs affect biological responses by inducing inflammation and genotoxicity, as a result of the cell–wMP interactions, also including the uptake of the smaller particles. John Wiley and Sons Inc. 2022-08-30 2022-12 /pmc/articles/PMC9805234/ /pubmed/35929361 http://dx.doi.org/10.1002/jat.4372 Text en © 2022 The Authors. Journal of Applied Toxicology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Bengalli, Rossella Zerboni, Alessandra Bonfanti, Patrizia Saibene, Melissa Mehn, Dora Cella, Claudia Ponti, Jessica La Spina, Rita Mantecca, Paride Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells |
title | Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells |
title_full | Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells |
title_fullStr | Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells |
title_full_unstemmed | Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells |
title_short | Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells |
title_sort | characterization of microparticles derived from waste plastics and their bio‐interaction with human lung a549 cells |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805234/ https://www.ncbi.nlm.nih.gov/pubmed/35929361 http://dx.doi.org/10.1002/jat.4372 |
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