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Development of an Allenyne‐Alkyne [4+2] Cycloaddition and its Application to Total Synthesis of Selaginpulvilin A

A new [4+2] cycloaddition of allenyne‐alkyne is developed. The reaction is believed to proceed with forming an α,3‐dehydrotoluene intermediate. This species behaves as a σπ‐diradical to react with a hydrogen atom donor, whereas it displays a zwitterionic reactivity toward weak nucleophiles. The effi...

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Detalles Bibliográficos
Autores principales: Le, Anh, Gupta, Saswata, Xu, Man, Xia, Yuanzhi, Lee, Daesung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805236/
https://www.ncbi.nlm.nih.gov/pubmed/35771213
http://dx.doi.org/10.1002/chem.202202015