Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma

Herein, we review evidence that targeting mitochondrial dysfunction with ‘mitoceuticals’ is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism....

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Autores principales: Patel, Samir P., Michael, Felicia M., Gollihue, Jenna L., Hubbard, W. Brad, Sullivan, Patrick G., Rabchevsky, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805511/
https://www.ncbi.nlm.nih.gov/pubmed/36371072
http://dx.doi.org/10.1016/j.mito.2022.11.001
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author Patel, Samir P.
Michael, Felicia M.
Gollihue, Jenna L.
Hubbard, W. Brad
Sullivan, Patrick G.
Rabchevsky, Alexander G.
author_facet Patel, Samir P.
Michael, Felicia M.
Gollihue, Jenna L.
Hubbard, W. Brad
Sullivan, Patrick G.
Rabchevsky, Alexander G.
author_sort Patel, Samir P.
collection PubMed
description Herein, we review evidence that targeting mitochondrial dysfunction with ‘mitoceuticals’ is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.
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spelling pubmed-98055112023-01-01 Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma Patel, Samir P. Michael, Felicia M. Gollihue, Jenna L. Hubbard, W. Brad Sullivan, Patrick G. Rabchevsky, Alexander G. Mitochondrion Article Herein, we review evidence that targeting mitochondrial dysfunction with ‘mitoceuticals’ is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord. 2023-01 2022-11-09 /pmc/articles/PMC9805511/ /pubmed/36371072 http://dx.doi.org/10.1016/j.mito.2022.11.001 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Patel, Samir P.
Michael, Felicia M.
Gollihue, Jenna L.
Hubbard, W. Brad
Sullivan, Patrick G.
Rabchevsky, Alexander G.
Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
title Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
title_full Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
title_fullStr Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
title_full_unstemmed Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
title_short Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
title_sort delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805511/
https://www.ncbi.nlm.nih.gov/pubmed/36371072
http://dx.doi.org/10.1016/j.mito.2022.11.001
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