CoMutDB: the landscape of somatic mutation co-occurrence in cancers

MOTIVATION: Somatic mutation co-occurrence has been proven to have a profound effect on tumorigenesis. While some studies have been conducted on co-mutations, a centralized resource dedicated to co-mutations in cancer is still lacking. RESULTS: Using multi-omics data from over 30 000 subjects and 17...

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Detalles Bibliográficos
Autores principales: Jiang, Limin, Yu, Hui, Tang, Jijun, Guo, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Applications Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805589/
https://www.ncbi.nlm.nih.gov/pubmed/36355452
http://dx.doi.org/10.1093/bioinformatics/btac725
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author Jiang, Limin
Yu, Hui
Tang, Jijun
Guo, Yan
author_facet Jiang, Limin
Yu, Hui
Tang, Jijun
Guo, Yan
author_sort Jiang, Limin
collection PubMed
description MOTIVATION: Somatic mutation co-occurrence has been proven to have a profound effect on tumorigenesis. While some studies have been conducted on co-mutations, a centralized resource dedicated to co-mutations in cancer is still lacking. RESULTS: Using multi-omics data from over 30 000 subjects and 1747 cancer cell lines, we present the Cancer co-mutation database (CoMutDB), the most comprehensive resource devoted to describing cancer co-mutations and their characteristics. AVAILABILITY AND IMPLEMENTATION: The data underlying this article are available in the online database CoMutDB: http://www.innovebioinfo.com/Database/CoMutDB/Home.php.
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spelling pubmed-98055892023-01-03 CoMutDB: the landscape of somatic mutation co-occurrence in cancers Jiang, Limin Yu, Hui Tang, Jijun Guo, Yan Bioinformatics Applications Note MOTIVATION: Somatic mutation co-occurrence has been proven to have a profound effect on tumorigenesis. While some studies have been conducted on co-mutations, a centralized resource dedicated to co-mutations in cancer is still lacking. RESULTS: Using multi-omics data from over 30 000 subjects and 1747 cancer cell lines, we present the Cancer co-mutation database (CoMutDB), the most comprehensive resource devoted to describing cancer co-mutations and their characteristics. AVAILABILITY AND IMPLEMENTATION: The data underlying this article are available in the online database CoMutDB: http://www.innovebioinfo.com/Database/CoMutDB/Home.php. Oxford University Press 2022-11-10 /pmc/articles/PMC9805589/ /pubmed/36355452 http://dx.doi.org/10.1093/bioinformatics/btac725 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Note
Jiang, Limin
Yu, Hui
Tang, Jijun
Guo, Yan
CoMutDB: the landscape of somatic mutation co-occurrence in cancers
title CoMutDB: the landscape of somatic mutation co-occurrence in cancers
title_full CoMutDB: the landscape of somatic mutation co-occurrence in cancers
title_fullStr CoMutDB: the landscape of somatic mutation co-occurrence in cancers
title_full_unstemmed CoMutDB: the landscape of somatic mutation co-occurrence in cancers
title_short CoMutDB: the landscape of somatic mutation co-occurrence in cancers
title_sort comutdb: the landscape of somatic mutation co-occurrence in cancers
topic Applications Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805589/
https://www.ncbi.nlm.nih.gov/pubmed/36355452
http://dx.doi.org/10.1093/bioinformatics/btac725
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AT tangjijun comutdbthelandscapeofsomaticmutationcooccurrenceincancers
AT guoyan comutdbthelandscapeofsomaticmutationcooccurrenceincancers

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