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Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells

BACKGROUND: Pathogenic mutations in WRN are a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the skeletal system, characterized by short stature, light body weight and unusually...

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Detalles Bibliográficos
Autores principales:	Leung, Adrian On-Wah, Yiu, Tsz-Ching, Liu, Lingxiao, Tam, Hei-Yin, Gu, Shen, Tu, Jiajie, Pei, Duanqing, Cheung, Hoi-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805690/ https://www.ncbi.nlm.nih.gov/pubmed/36587229 http://dx.doi.org/10.1186/s13578-022-00939-8

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