Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103(+) dendritic cell IL-23-dependent ileocolitis

Endoplasmic reticulum (ER) stress is associated with Crohn’s disease (CD), but its impact on host-microbe interaction in disease pathogenesis is not well defined. Functional deficiency in the protein disulfide isomerase anterior gradient 2 (AGR2) has been linked with CD and leads to epithelial cell...

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Detalles Bibliográficos
Autores principales: Viladomiu, Monica, Khounlotham, Manirath, Dogan, Belgin, Lima, Svetlana F., Elsaadi, Ahmed, Cardakli, Emre, Castellanos, Jim G., Ng, Charles, Herzog, Jeremy, Schoenborn, Alexi A., Ellermann, Melissa, Liu, Bo, Zhang, Shiying, Gulati, Ajay S., Sartor, R. Balfour, Simpson, Kenneth W., Lipkin, Steven M., Longman, Randy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805753/
https://www.ncbi.nlm.nih.gov/pubmed/36384110
http://dx.doi.org/10.1016/j.celrep.2022.111637

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