A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum

Systemic mastocytosis (SM) is a heterogeneous group of disorders caused by mast cell proliferation. SM often presents with non-specific symptoms making it a diagnostic challenge. Moreover, presentation with bone involvement is highly uncommon. Here, we report a rare case of SM in a 68-year-old femal...

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Detalles Bibliográficos
Autores principales: Ghorpade, Rina, Tissavirasingham, Fiona, Vennepureddy, Adarsh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805796/
https://www.ncbi.nlm.nih.gov/pubmed/36601202
http://dx.doi.org/10.7759/cureus.32135
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author Ghorpade, Rina
Tissavirasingham, Fiona
Vennepureddy, Adarsh
author_facet Ghorpade, Rina
Tissavirasingham, Fiona
Vennepureddy, Adarsh
author_sort Ghorpade, Rina
collection PubMed
description Systemic mastocytosis (SM) is a heterogeneous group of disorders caused by mast cell proliferation. SM often presents with non-specific symptoms making it a diagnostic challenge. Moreover, presentation with bone involvement is highly uncommon. Here, we report a rare case of SM in a 68-year-old female who initially presented with gastrointestinal symptoms and was later found to have sclerotic bone lesions on imaging. This case highlights an unusual presentation of SM, informing clinicians of the importance of keeping this disease process on the differential list of diagnostic conundrums.
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spelling pubmed-98057962023-01-03 A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum Ghorpade, Rina Tissavirasingham, Fiona Vennepureddy, Adarsh Cureus Internal Medicine Systemic mastocytosis (SM) is a heterogeneous group of disorders caused by mast cell proliferation. SM often presents with non-specific symptoms making it a diagnostic challenge. Moreover, presentation with bone involvement is highly uncommon. Here, we report a rare case of SM in a 68-year-old female who initially presented with gastrointestinal symptoms and was later found to have sclerotic bone lesions on imaging. This case highlights an unusual presentation of SM, informing clinicians of the importance of keeping this disease process on the differential list of diagnostic conundrums. Cureus 2022-12-02 /pmc/articles/PMC9805796/ /pubmed/36601202 http://dx.doi.org/10.7759/cureus.32135 Text en Copyright © 2022, Ghorpade et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ghorpade, Rina
Tissavirasingham, Fiona
Vennepureddy, Adarsh
A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum
title A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum
title_full A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum
title_fullStr A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum
title_full_unstemmed A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum
title_short A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum
title_sort rare case of aggressive systemic mastocytosis with skeletal osteosclerotic lesions on presentation: a diagnostic conundrum
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805796/
https://www.ncbi.nlm.nih.gov/pubmed/36601202
http://dx.doi.org/10.7759/cureus.32135
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