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Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups

Mouse pups produce. ultrasonic vocalizations (USVs) in response to isolation from the nest (i.e., isolation USVs). Rates and acoustic features of isolation USVs change dramatically over the first two weeks of life, and there is also substantial variability in the rates and acoustic features of isola...

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Autores principales: Pranic, Nicole M., Kornbrek, Caroline, Yang, Chen, Cleland, Thomas A., Tschida, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805956/
https://www.ncbi.nlm.nih.gov/pubmed/36600992
http://dx.doi.org/10.3389/fnbeh.2022.1015484
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author Pranic, Nicole M.
Kornbrek, Caroline
Yang, Chen
Cleland, Thomas A.
Tschida, Katherine A.
author_facet Pranic, Nicole M.
Kornbrek, Caroline
Yang, Chen
Cleland, Thomas A.
Tschida, Katherine A.
author_sort Pranic, Nicole M.
collection PubMed
description Mouse pups produce. ultrasonic vocalizations (USVs) in response to isolation from the nest (i.e., isolation USVs). Rates and acoustic features of isolation USVs change dramatically over the first two weeks of life, and there is also substantial variability in the rates and acoustic features of isolation USVs at a given postnatal age. The factors that contribute to within age variability in isolation USVs remain largely unknown. Here, we explore the extent to which non-vocal behaviors of mouse pups relate to the within age variability in rates and acoustic features of their USVs. We recorded non-vocal behaviors of isolated C57BL/6J mouse pups at four postnatal ages (postnatal days 5, 10, 15, and 20), measured rates of isolation USV production, and applied a combination of pre-defined acoustic feature measurements and an unsupervised machine learning-based vocal analysis method to examine USV acoustic features. When we considered different categories of non-vocal behavior, our analyses revealed that mice in all postnatal age groups produce higher rates of isolation USVs during active non-vocal behaviors than when lying still. Moreover, rates of isolation USVs are correlated with the intensity (i.e., magnitude) of non-vocal body and limb movements within a given trial. In contrast, USVs produced during different categories of non-vocal behaviors and during different intensities of non-vocal movement do not differ substantially in their acoustic features. Our findings suggest that levels of behavioral arousal contribute to within age variability in rates, but not acoustic features, of mouse isolation USVs
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spelling pubmed-98059562023-01-03 Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups Pranic, Nicole M. Kornbrek, Caroline Yang, Chen Cleland, Thomas A. Tschida, Katherine A. Front Behav Neurosci Behavioral Neuroscience Mouse pups produce. ultrasonic vocalizations (USVs) in response to isolation from the nest (i.e., isolation USVs). Rates and acoustic features of isolation USVs change dramatically over the first two weeks of life, and there is also substantial variability in the rates and acoustic features of isolation USVs at a given postnatal age. The factors that contribute to within age variability in isolation USVs remain largely unknown. Here, we explore the extent to which non-vocal behaviors of mouse pups relate to the within age variability in rates and acoustic features of their USVs. We recorded non-vocal behaviors of isolated C57BL/6J mouse pups at four postnatal ages (postnatal days 5, 10, 15, and 20), measured rates of isolation USV production, and applied a combination of pre-defined acoustic feature measurements and an unsupervised machine learning-based vocal analysis method to examine USV acoustic features. When we considered different categories of non-vocal behavior, our analyses revealed that mice in all postnatal age groups produce higher rates of isolation USVs during active non-vocal behaviors than when lying still. Moreover, rates of isolation USVs are correlated with the intensity (i.e., magnitude) of non-vocal body and limb movements within a given trial. In contrast, USVs produced during different categories of non-vocal behaviors and during different intensities of non-vocal movement do not differ substantially in their acoustic features. Our findings suggest that levels of behavioral arousal contribute to within age variability in rates, but not acoustic features, of mouse isolation USVs Frontiers Media S.A. 2022-12-19 /pmc/articles/PMC9805956/ /pubmed/36600992 http://dx.doi.org/10.3389/fnbeh.2022.1015484 Text en Copyright © 2022 Pranic, Kornbrek, Yang, Cleland and Tschida. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Pranic, Nicole M.
Kornbrek, Caroline
Yang, Chen
Cleland, Thomas A.
Tschida, Katherine A.
Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups
title Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups
title_full Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups
title_fullStr Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups
title_full_unstemmed Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups
title_short Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups
title_sort rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805956/
https://www.ncbi.nlm.nih.gov/pubmed/36600992
http://dx.doi.org/10.3389/fnbeh.2022.1015484
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