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Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies

Myelin oligodendrocyte glycoprotein (MOG) antibodies have been identified in central nervous system inflammatory demyelinating disorders (MOG antibody disease), inclusive of optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis. The association of MOG antibodies with combined...

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Autores principales: Elterefi, Alanood E, Elbashari, Mahfoud Y, Alzaabi, Amani, Abouelnaga, Mohamed E, Eissa, Hesham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805985/
https://www.ncbi.nlm.nih.gov/pubmed/36601183
http://dx.doi.org/10.7759/cureus.32143
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author Elterefi, Alanood E
Elbashari, Mahfoud Y
Alzaabi, Amani
Abouelnaga, Mohamed E
Eissa, Hesham
author_facet Elterefi, Alanood E
Elbashari, Mahfoud Y
Alzaabi, Amani
Abouelnaga, Mohamed E
Eissa, Hesham
author_sort Elterefi, Alanood E
collection PubMed
description Myelin oligodendrocyte glycoprotein (MOG) antibodies have been identified in central nervous system inflammatory demyelinating disorders (MOG antibody disease), inclusive of optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis. The association of MOG antibodies with combined central and peripheral demyelination (CCPD) is not clear. It has been reported in a few cases where MOG antibodies were detected in the serum of patients with chronic inflammatory demyelinating polyneuropathy. However, multifocal motor neuropathy with MOG antibodies is extremely rare. We present a patient who had clinical, neurophysiological, radiological, and biochemical findings that support the diagnosis of CCPD (multifocal motor neuropathy and cord lesion) with MOG antibodies. The patient was treated with a combination therapy of intravenous immunoglobulins plus high-dose methylprednisolone, which resulted in significant improvement.
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spelling pubmed-98059852023-01-03 Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies Elterefi, Alanood E Elbashari, Mahfoud Y Alzaabi, Amani Abouelnaga, Mohamed E Eissa, Hesham Cureus Internal Medicine Myelin oligodendrocyte glycoprotein (MOG) antibodies have been identified in central nervous system inflammatory demyelinating disorders (MOG antibody disease), inclusive of optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis. The association of MOG antibodies with combined central and peripheral demyelination (CCPD) is not clear. It has been reported in a few cases where MOG antibodies were detected in the serum of patients with chronic inflammatory demyelinating polyneuropathy. However, multifocal motor neuropathy with MOG antibodies is extremely rare. We present a patient who had clinical, neurophysiological, radiological, and biochemical findings that support the diagnosis of CCPD (multifocal motor neuropathy and cord lesion) with MOG antibodies. The patient was treated with a combination therapy of intravenous immunoglobulins plus high-dose methylprednisolone, which resulted in significant improvement. Cureus 2022-12-02 /pmc/articles/PMC9805985/ /pubmed/36601183 http://dx.doi.org/10.7759/cureus.32143 Text en Copyright © 2022, Elterefi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Elterefi, Alanood E
Elbashari, Mahfoud Y
Alzaabi, Amani
Abouelnaga, Mohamed E
Eissa, Hesham
Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies
title Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies
title_full Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies
title_fullStr Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies
title_full_unstemmed Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies
title_short Combined Central and Peripheral Demyelination in a Patient of Multifocal Motor Neuropathy and Positive Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibodies
title_sort combined central and peripheral demyelination in a patient of multifocal motor neuropathy and positive anti-myelin oligodendrocyte glycoprotein (mog) antibodies
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805985/
https://www.ncbi.nlm.nih.gov/pubmed/36601183
http://dx.doi.org/10.7759/cureus.32143
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