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Optic neuromyelitis after vaccination against SARS-CoV-2
Neuromyelitis optica is an autoimmune demyelinating astrocytopathy of the central nervous system that primarily affects the optic nerve and spinal cord. It is considered a multifactorial disease associated with antibodies against aquaporin 4, with complement cascade activation and lymphocytic infilt...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806042/ https://www.ncbi.nlm.nih.gov/pubmed/36574993 http://dx.doi.org/10.1136/bcr-2022-252309 |
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author | Hernandez-Vega, Melissa Orozco-Narvaez, Alejandro Reyes-Vaca, Jorge Guillermo Rodriguez-Leyva, Ildefonso |
author_facet | Hernandez-Vega, Melissa Orozco-Narvaez, Alejandro Reyes-Vaca, Jorge Guillermo Rodriguez-Leyva, Ildefonso |
author_sort | Hernandez-Vega, Melissa |
collection | PubMed |
description | Neuromyelitis optica is an autoimmune demyelinating astrocytopathy of the central nervous system that primarily affects the optic nerve and spinal cord. It is considered a multifactorial disease associated with antibodies against aquaporin 4, with complement cascade activation and lymphocytic infiltration leading to axonal loss and causing significant morbidity and disability. In addition, cases of inflammatory diseases of the central nervous system have been described after vaccination against SARS-CoV-2, mainly acute disseminated encephalomyelitis. Also, a few cases of neuromyelitis optica spectrum disorder, mostly aquaporin 4+, have been reported. We describe a patient who developed symptoms suggestive of acute disseminated encephalomyelitis the next day after vaccination against SARS-CoV-2. Three months later, a longitudinally extensive transverse myelitis compatible with aquaporin 4+ neuromyelitis optica was successfully treated with an interleukin 6 inhibitor. There is no proven association and research is needed to establish whether optic neuromyelitis is related to vaccination; this is a single case report from which no conclusion can be drawn. |
format | Online Article Text |
id | pubmed-9806042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-98060422023-01-03 Optic neuromyelitis after vaccination against SARS-CoV-2 Hernandez-Vega, Melissa Orozco-Narvaez, Alejandro Reyes-Vaca, Jorge Guillermo Rodriguez-Leyva, Ildefonso BMJ Case Rep Case Reports: Rare disease Neuromyelitis optica is an autoimmune demyelinating astrocytopathy of the central nervous system that primarily affects the optic nerve and spinal cord. It is considered a multifactorial disease associated with antibodies against aquaporin 4, with complement cascade activation and lymphocytic infiltration leading to axonal loss and causing significant morbidity and disability. In addition, cases of inflammatory diseases of the central nervous system have been described after vaccination against SARS-CoV-2, mainly acute disseminated encephalomyelitis. Also, a few cases of neuromyelitis optica spectrum disorder, mostly aquaporin 4+, have been reported. We describe a patient who developed symptoms suggestive of acute disseminated encephalomyelitis the next day after vaccination against SARS-CoV-2. Three months later, a longitudinally extensive transverse myelitis compatible with aquaporin 4+ neuromyelitis optica was successfully treated with an interleukin 6 inhibitor. There is no proven association and research is needed to establish whether optic neuromyelitis is related to vaccination; this is a single case report from which no conclusion can be drawn. BMJ Publishing Group 2022-12-27 /pmc/articles/PMC9806042/ /pubmed/36574993 http://dx.doi.org/10.1136/bcr-2022-252309 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ. |
spellingShingle | Case Reports: Rare disease Hernandez-Vega, Melissa Orozco-Narvaez, Alejandro Reyes-Vaca, Jorge Guillermo Rodriguez-Leyva, Ildefonso Optic neuromyelitis after vaccination against SARS-CoV-2 |
title | Optic neuromyelitis after vaccination against SARS-CoV-2 |
title_full | Optic neuromyelitis after vaccination against SARS-CoV-2 |
title_fullStr | Optic neuromyelitis after vaccination against SARS-CoV-2 |
title_full_unstemmed | Optic neuromyelitis after vaccination against SARS-CoV-2 |
title_short | Optic neuromyelitis after vaccination against SARS-CoV-2 |
title_sort | optic neuromyelitis after vaccination against sars-cov-2 |
topic | Case Reports: Rare disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806042/ https://www.ncbi.nlm.nih.gov/pubmed/36574993 http://dx.doi.org/10.1136/bcr-2022-252309 |
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