Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

Fibroblast activation protein (Fap) is a serine protease that degrades denatured type I collagen, α2-antiplasmin and FGF21. Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin (Oln). Fap is also exp...

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Detalles Bibliográficos
Autores principales: Fan, Aoyuan, Wu, Genbin, Wang, Jianfang, Lu, Laiya, Wang, Jingyi, Wei, Hanjing, Sun, Yuxi, Xu, Yanhua, Mo, Chunyang, Zhang, Xiaoying, Pang, Zhiying, Pan, Zhangyi, Wang, Yiming, Lu, Liangyu, Fu, Guojian, Ma, Mengqiu, Zhu, Qiaoling, Cao, Dandan, Qin, Jiachen, Yin, Feng, Yue, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806108/
https://www.ncbi.nlm.nih.gov/pubmed/36588124
http://dx.doi.org/10.1038/s41413-022-00243-8

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