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Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to cause immune dysregulation and, therefore, has varied and often rare presentations. Rosai–Dorfman–Destombes disease (RDD) is an unusual non-Langerhans cell (non-LC) histiocytosis pr...

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Autores principales: Gogia, Pooja, Tanni, Fahmina, Coca-Guzman, Juan, Chen, Neil, Huang, Yiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806133/
https://www.ncbi.nlm.nih.gov/pubmed/36600887
http://dx.doi.org/10.3389/fmed.2022.1073767
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author Gogia, Pooja
Tanni, Fahmina
Coca-Guzman, Juan
Chen, Neil
Huang, Yiwu
author_facet Gogia, Pooja
Tanni, Fahmina
Coca-Guzman, Juan
Chen, Neil
Huang, Yiwu
author_sort Gogia, Pooja
collection PubMed
description Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to cause immune dysregulation and, therefore, has varied and often rare presentations. Rosai–Dorfman–Destombes disease (RDD) is an unusual non-Langerhans cell (non-LC) histiocytosis presenting with massive lymphadenopathy and various systemic symptoms. A 55-year-old Asian-American woman with no significant medical history or recent use of new drugs initially presented with cervical lymphadenopathy and urticarial rash 1 week after receiving the COVID-19 messenger RNA (mRNA) vaccine (Moderna, mRNA-1273) against SARS-CoV-2. The biopsy of the skin rash was consistent with a drug reaction. Approximately 2 months later, she developed mild flu-like symptoms and was diagnosed with a COVID-19 infection. Her symptoms were mild and self-resolving. Approximately 3 months later, she developed a generalized patchy erythematous rash on the face and the body that gradually worsened; diffuse lymphadenopathy involving the bilateral cervical, axillary, and inguinal areas; and constitutional symptoms. Laboratory results were consistent with lymphopenia, anemia, and an elevated sedimentation rate. Supraclavicular lymph node biopsy showed Rosai–Dorfman disease with a marked polyclonal plasmacytosis. She was started on a tapering dose of corticosteroids and showed clinical improvements over the next few weeks. Herein, we present a rare case of a histiocytic disorder that developed after contracting the SARS-COV2 infection in the event of receiving a recent mRNA COVID vaccination.
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spelling pubmed-98061332023-01-03 Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection Gogia, Pooja Tanni, Fahmina Coca-Guzman, Juan Chen, Neil Huang, Yiwu Front Med (Lausanne) Medicine Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to cause immune dysregulation and, therefore, has varied and often rare presentations. Rosai–Dorfman–Destombes disease (RDD) is an unusual non-Langerhans cell (non-LC) histiocytosis presenting with massive lymphadenopathy and various systemic symptoms. A 55-year-old Asian-American woman with no significant medical history or recent use of new drugs initially presented with cervical lymphadenopathy and urticarial rash 1 week after receiving the COVID-19 messenger RNA (mRNA) vaccine (Moderna, mRNA-1273) against SARS-CoV-2. The biopsy of the skin rash was consistent with a drug reaction. Approximately 2 months later, she developed mild flu-like symptoms and was diagnosed with a COVID-19 infection. Her symptoms were mild and self-resolving. Approximately 3 months later, she developed a generalized patchy erythematous rash on the face and the body that gradually worsened; diffuse lymphadenopathy involving the bilateral cervical, axillary, and inguinal areas; and constitutional symptoms. Laboratory results were consistent with lymphopenia, anemia, and an elevated sedimentation rate. Supraclavicular lymph node biopsy showed Rosai–Dorfman disease with a marked polyclonal plasmacytosis. She was started on a tapering dose of corticosteroids and showed clinical improvements over the next few weeks. Herein, we present a rare case of a histiocytic disorder that developed after contracting the SARS-COV2 infection in the event of receiving a recent mRNA COVID vaccination. Frontiers Media S.A. 2022-12-19 /pmc/articles/PMC9806133/ /pubmed/36600887 http://dx.doi.org/10.3389/fmed.2022.1073767 Text en Copyright © 2022 Gogia, Tanni, Coca-Guzman, Chen and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Gogia, Pooja
Tanni, Fahmina
Coca-Guzman, Juan
Chen, Neil
Huang, Yiwu
Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection
title Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection
title_full Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection
title_fullStr Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection
title_full_unstemmed Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection
title_short Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection
title_sort case report: a rare case of rosai–dorfman–destombes disease after the covid-19 infection
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806133/
https://www.ncbi.nlm.nih.gov/pubmed/36600887
http://dx.doi.org/10.3389/fmed.2022.1073767
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