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Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury

Foot drop is a common clinical gait impairment characterized by the inability to raise the foot or toes during walking due to the weakness of the dorsiflexors of the foot. Lumbar spine disorders are common neurogenic causes of foot drop. The accurate prognosis and treatment protocols of foot drop ar...

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Autores principales: Chan, Shu-Yen, Kuo, Chi-Wei, Liao, Tsai-Tsen, Peng, Chih-Wei, Hsieh, Tsung-Hsun, Chang, Ming-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806139/
https://www.ncbi.nlm.nih.gov/pubmed/36601128
http://dx.doi.org/10.3389/fnhum.2022.972316
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author Chan, Shu-Yen
Kuo, Chi-Wei
Liao, Tsai-Tsen
Peng, Chih-Wei
Hsieh, Tsung-Hsun
Chang, Ming-Yuan
author_facet Chan, Shu-Yen
Kuo, Chi-Wei
Liao, Tsai-Tsen
Peng, Chih-Wei
Hsieh, Tsung-Hsun
Chang, Ming-Yuan
author_sort Chan, Shu-Yen
collection PubMed
description Foot drop is a common clinical gait impairment characterized by the inability to raise the foot or toes during walking due to the weakness of the dorsiflexors of the foot. Lumbar spine disorders are common neurogenic causes of foot drop. The accurate prognosis and treatment protocols of foot drop are not well delineated in the scientific literature due to the heterogeneity of the underlying lumbar spine disorders, different severities, and distinct definitions of the disease. For translational purposes, the use of animal disease models could be the best way to investigate the pathogenesis of foot drop and help develop effective therapeutic strategies for foot drops. However, no relevant and reproducible foot drop animal models with a suitable gait analysis method were developed for the observation of foot drop symptoms. Therefore, the present study aimed to develop a ventral root avulsion (VRA)-induced foot drop rat model and record detailed time-course changes of gait pattern following L5, L6, or L5 + L6 VRA surgery. Our results suggested that L5 + L6 VRA rats exhibited changes in gait patterns, as compared to sham lesion rats, including a significant reduction of walking speed, step length, toe spread, and swing phase time, as well as an increased duration of the stance phase time. The ankle kinematic data exhibited that the ankle joint angle increased during the mid-swing stage, indicating a significant foot drop pattern during locomotion. Time-course observations displayed that these gait impairments occurred as early as the first-day post-lesion and gradually recovered 7–14 days post-injury. We conclude that the proposed foot drop rat model with a video-based gait analysis approach can precisely detect the foot drop pattern induced by VRA in rats, which can provide insight into the compensatory changes and recovery in gait patterns and might be useful for serving as a translational platform bridging human and animal studies for developing novel therapeutic strategies for foot drop.
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spelling pubmed-98061392023-01-03 Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury Chan, Shu-Yen Kuo, Chi-Wei Liao, Tsai-Tsen Peng, Chih-Wei Hsieh, Tsung-Hsun Chang, Ming-Yuan Front Hum Neurosci Human Neuroscience Foot drop is a common clinical gait impairment characterized by the inability to raise the foot or toes during walking due to the weakness of the dorsiflexors of the foot. Lumbar spine disorders are common neurogenic causes of foot drop. The accurate prognosis and treatment protocols of foot drop are not well delineated in the scientific literature due to the heterogeneity of the underlying lumbar spine disorders, different severities, and distinct definitions of the disease. For translational purposes, the use of animal disease models could be the best way to investigate the pathogenesis of foot drop and help develop effective therapeutic strategies for foot drops. However, no relevant and reproducible foot drop animal models with a suitable gait analysis method were developed for the observation of foot drop symptoms. Therefore, the present study aimed to develop a ventral root avulsion (VRA)-induced foot drop rat model and record detailed time-course changes of gait pattern following L5, L6, or L5 + L6 VRA surgery. Our results suggested that L5 + L6 VRA rats exhibited changes in gait patterns, as compared to sham lesion rats, including a significant reduction of walking speed, step length, toe spread, and swing phase time, as well as an increased duration of the stance phase time. The ankle kinematic data exhibited that the ankle joint angle increased during the mid-swing stage, indicating a significant foot drop pattern during locomotion. Time-course observations displayed that these gait impairments occurred as early as the first-day post-lesion and gradually recovered 7–14 days post-injury. We conclude that the proposed foot drop rat model with a video-based gait analysis approach can precisely detect the foot drop pattern induced by VRA in rats, which can provide insight into the compensatory changes and recovery in gait patterns and might be useful for serving as a translational platform bridging human and animal studies for developing novel therapeutic strategies for foot drop. Frontiers Media S.A. 2022-12-19 /pmc/articles/PMC9806139/ /pubmed/36601128 http://dx.doi.org/10.3389/fnhum.2022.972316 Text en Copyright © 2022 Chan, Kuo, Liao, Peng, Hsieh and Chang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Chan, Shu-Yen
Kuo, Chi-Wei
Liao, Tsai-Tsen
Peng, Chih-Wei
Hsieh, Tsung-Hsun
Chang, Ming-Yuan
Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
title Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
title_full Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
title_fullStr Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
title_full_unstemmed Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
title_short Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
title_sort time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806139/
https://www.ncbi.nlm.nih.gov/pubmed/36601128
http://dx.doi.org/10.3389/fnhum.2022.972316
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