Cargando…
The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease
Diabetic kidney disease (DKD), an emerging global health issue, is one of the most severe microvascular complications derived from diabetes and a primary pathology contributing to end-stage renal disease. The currently available treatment provides only symptomatic relief and has failed to delay the...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806165/ https://www.ncbi.nlm.nih.gov/pubmed/36601125 http://dx.doi.org/10.3389/fimmu.2022.1080456 |
_version_ | 1784862477212712960 |
---|---|
author | Tao, Pengyu Ji, Jing Wang, Qian Cui, Mengmeng Cao, Mingfeng Xu, Yuzhen |
author_facet | Tao, Pengyu Ji, Jing Wang, Qian Cui, Mengmeng Cao, Mingfeng Xu, Yuzhen |
author_sort | Tao, Pengyu |
collection | PubMed |
description | Diabetic kidney disease (DKD), an emerging global health issue, is one of the most severe microvascular complications derived from diabetes and a primary pathology contributing to end-stage renal disease. The currently available treatment provides only symptomatic relief and has failed to delay the progression of DKD into chronic kidney disease. Recently, multiple studies have proposed a strong link between intestinal dysbiosis and the occurrence of DKD. The gut microbiota-derived short-chain fatty acids (SCFAs) capable of regulating inflammation, oxidative stress, fibrosis, and energy metabolism have been considered versatile players in the prevention and treatment of DKD. However, the underlying molecular mechanism of the intervention of the gut microbiota–kidney axis in the development of DKD still remains to be explored. This review provides insight into the contributory role of gut microbiota-derived SCFAs in DKD. |
format | Online Article Text |
id | pubmed-9806165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98061652023-01-03 The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease Tao, Pengyu Ji, Jing Wang, Qian Cui, Mengmeng Cao, Mingfeng Xu, Yuzhen Front Immunol Immunology Diabetic kidney disease (DKD), an emerging global health issue, is one of the most severe microvascular complications derived from diabetes and a primary pathology contributing to end-stage renal disease. The currently available treatment provides only symptomatic relief and has failed to delay the progression of DKD into chronic kidney disease. Recently, multiple studies have proposed a strong link between intestinal dysbiosis and the occurrence of DKD. The gut microbiota-derived short-chain fatty acids (SCFAs) capable of regulating inflammation, oxidative stress, fibrosis, and energy metabolism have been considered versatile players in the prevention and treatment of DKD. However, the underlying molecular mechanism of the intervention of the gut microbiota–kidney axis in the development of DKD still remains to be explored. This review provides insight into the contributory role of gut microbiota-derived SCFAs in DKD. Frontiers Media S.A. 2022-12-19 /pmc/articles/PMC9806165/ /pubmed/36601125 http://dx.doi.org/10.3389/fimmu.2022.1080456 Text en Copyright © 2022 Tao, Ji, Wang, Cui, Cao and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Tao, Pengyu Ji, Jing Wang, Qian Cui, Mengmeng Cao, Mingfeng Xu, Yuzhen The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease |
title | The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease |
title_full | The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease |
title_fullStr | The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease |
title_full_unstemmed | The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease |
title_short | The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease |
title_sort | role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806165/ https://www.ncbi.nlm.nih.gov/pubmed/36601125 http://dx.doi.org/10.3389/fimmu.2022.1080456 |
work_keys_str_mv | AT taopengyu theroleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT jijing theroleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT wangqian theroleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT cuimengmeng theroleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT caomingfeng theroleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT xuyuzhen theroleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT taopengyu roleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT jijing roleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT wangqian roleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT cuimengmeng roleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT caomingfeng roleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease AT xuyuzhen roleandmechanismofgutmicrobiotaderivedshortchainfattyinthepreventionandtreatmentofdiabetickidneydisease |