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Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice

Rheumatoid arthritis is one of the most common diseases in orthopedic surgery. The main symptoms are joint pain and systemic symptoms. In recent years, rheumatoid arthritis is known to cause sarcopenia. Ninjin’yoeito (NYT), a traditional Japanese medicine, has been prescribed for patients with post-...

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Autores principales: Suginohara, Takeshi, Kawaguchi, Megumi, Michihara, Seiwa, Fujita, Nina, Han, Li-Kun, Takahashi, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806168/
https://www.ncbi.nlm.nih.gov/pubmed/36601050
http://dx.doi.org/10.3389/fphar.2022.974380
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author Suginohara, Takeshi
Kawaguchi, Megumi
Michihara, Seiwa
Fujita, Nina
Han, Li-Kun
Takahashi, Ryuji
author_facet Suginohara, Takeshi
Kawaguchi, Megumi
Michihara, Seiwa
Fujita, Nina
Han, Li-Kun
Takahashi, Ryuji
author_sort Suginohara, Takeshi
collection PubMed
description Rheumatoid arthritis is one of the most common diseases in orthopedic surgery. The main symptoms are joint pain and systemic symptoms. In recent years, rheumatoid arthritis is known to cause sarcopenia. Ninjin’yoeito (NYT), a traditional Japanese medicine, has been prescribed for patients with post-illness or post-operative weakness, fatigue, loss of appetite, rash, cold limbs, and anemia. In addition to its traditional use, NYT has been prescribed for treating frailty in gastrointestinal, respiratory, and urinary functions. Further, NYT is known to be effective in suppressing muscle atrophy in the prior literature. The present study aimed to investigate whether NYT suppresses various symptoms of the Collagen-induced arthritis (CIA) model. Long-term administration of NYT inhibited the increases in arthritis scores, decreases pain threshold, and muscle atrophy in the CIA model. In addition, NYT inhibited the elevation of the plasma IL-6 level. These results suggest that NYT may have therapeutic effects on symptoms, muscle atrophy and increase in plasma IL-6 level caused by rheumatoid arthritis.
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spelling pubmed-98061682023-01-03 Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice Suginohara, Takeshi Kawaguchi, Megumi Michihara, Seiwa Fujita, Nina Han, Li-Kun Takahashi, Ryuji Front Pharmacol Pharmacology Rheumatoid arthritis is one of the most common diseases in orthopedic surgery. The main symptoms are joint pain and systemic symptoms. In recent years, rheumatoid arthritis is known to cause sarcopenia. Ninjin’yoeito (NYT), a traditional Japanese medicine, has been prescribed for patients with post-illness or post-operative weakness, fatigue, loss of appetite, rash, cold limbs, and anemia. In addition to its traditional use, NYT has been prescribed for treating frailty in gastrointestinal, respiratory, and urinary functions. Further, NYT is known to be effective in suppressing muscle atrophy in the prior literature. The present study aimed to investigate whether NYT suppresses various symptoms of the Collagen-induced arthritis (CIA) model. Long-term administration of NYT inhibited the increases in arthritis scores, decreases pain threshold, and muscle atrophy in the CIA model. In addition, NYT inhibited the elevation of the plasma IL-6 level. These results suggest that NYT may have therapeutic effects on symptoms, muscle atrophy and increase in plasma IL-6 level caused by rheumatoid arthritis. Frontiers Media S.A. 2022-12-19 /pmc/articles/PMC9806168/ /pubmed/36601050 http://dx.doi.org/10.3389/fphar.2022.974380 Text en Copyright © 2022 Suginohara, Kawaguchi, Michihara, Fujita, Han and Takahashi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Suginohara, Takeshi
Kawaguchi, Megumi
Michihara, Seiwa
Fujita, Nina
Han, Li-Kun
Takahashi, Ryuji
Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice
title Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice
title_full Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice
title_fullStr Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice
title_full_unstemmed Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice
title_short Ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice
title_sort ninjin’yoeito suppressed the onset of arthritis, pain, and muscle atrophy in rheumatoid arthritis model mice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806168/
https://www.ncbi.nlm.nih.gov/pubmed/36601050
http://dx.doi.org/10.3389/fphar.2022.974380
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