Novel assay to measure chromosome instability identifies Punica granatum extract that elevates CIN and has a potential for tumor- suppressing therapies

Human artificial chromosomes (HACs) have provided a useful tool to study kinetochore structure and function, gene delivery, and gene expression. The HAC propagates and segregates properly in the cells. Recently, we have developed an experimental high-throughput imaging (HTI) HAC-based assay that all...

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Detalles Bibliográficos
Autores principales: Goncharov, Nikolay V., Kovalskaia, Valeria A., Romanishin, Alexander O., Shved, Nikita A., Belousov, Andrei S., Tiasto, Vladlena S., Gulaia, Valeriia S., Neergheen, Vidushi S., Rummun, Nawraj, Liskovykh, Mikhail, Larionov, Vladimir, Kouprina, Natalay, Kumeiko, Vadim V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806258/
https://www.ncbi.nlm.nih.gov/pubmed/36601386
http://dx.doi.org/10.3389/fbioe.2022.989932

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