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Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells

An acidic environment and hypoxia within the tumour are hallmarks of cancer that contribute to cell resistance to therapy. Deregulation of the PI3K/Akt pathway is common in colon cancer. Numerous Akt‐targeted therapies are being developed, the activity of Akt‐inhibitors is, however, strongly pH‐depe...

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Detalles Bibliográficos
Autores principales:	Adamová, Barbora, Říhová, Kamila, Pokludová, Jana, Beneš, Petr, Šmarda, Jan, Navrátilová, Jarmila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806293/ https://www.ncbi.nlm.nih.gov/pubmed/36523175 http://dx.doi.org/10.1111/jcmm.17636

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