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Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis

PURPOSE: Presence of diabetes in glaucoma patients may influence findings while documenting the progression of glaucoma. We conducted the study to compare individual and combined effects of diabetes and glaucoma on macular thickness and ganglion cell complex thickness. METHODS: The present study is...

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Autores principales: Shah, Dhruven, Dhamankar, Rita, Shetty, Vijay, Haldipurkar, Suhas S, Chipade, Prakash, Tanwar, Shabnam, Sankhe, Prachi, Venkatramani, Devendra, Mhatre, Paresh, Setia, Maninder Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PUBLISHED BY KNOWLEDGE E 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806304/
https://www.ncbi.nlm.nih.gov/pubmed/36620706
http://dx.doi.org/10.18502/jovr.v17i4.12303
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author Shah, Dhruven
Dhamankar, Rita
Shetty, Vijay
Haldipurkar, Suhas S
Chipade, Prakash
Tanwar, Shabnam
Sankhe, Prachi
Venkatramani, Devendra
Mhatre, Paresh
Setia, Maninder Singh
author_facet Shah, Dhruven
Dhamankar, Rita
Shetty, Vijay
Haldipurkar, Suhas S
Chipade, Prakash
Tanwar, Shabnam
Sankhe, Prachi
Venkatramani, Devendra
Mhatre, Paresh
Setia, Maninder Singh
author_sort Shah, Dhruven
collection PubMed
description PURPOSE: Presence of diabetes in glaucoma patients may influence findings while documenting the progression of glaucoma. We conducted the study to compare individual and combined effects of diabetes and glaucoma on macular thickness and ganglion cell complex thickness. METHODS: The present study is a cross-sectional analysis of 172 eyes of 114 individuals. The groups were categorized according to the following conditions: glaucoma, diabetes mellitus, both glaucoma and diabetes (`both' group), and none of these conditions (`none' group). Patients with diabetes did not have diabetic retinopathy (DR). We compared retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal loss of volume (FLV), and global loss of volume (GLV) among the groups. We used random effects multivariate analysis to adjust for potential confounders. RESULTS: The mean (SD) age of these individuals was 60.7 (10.1) years. The total average RNFL and GCC were significantly lower in the glaucoma group (RNFL: -36.27, 95% confidence intervals [CI]: -42.79 to -29.74; P [Formula: see text] 0.05, and GCC: -26.24, 95% CI: -31.49 to -20.98; P [Formula: see text] 0.05) and the `both' group (RNFL: -24.74, 95% CI: -32.84 to -16.63; P [Formula: see text] 0.05, and GCC: -17.92, 95% CI: -24.58 to -11.26; P [Formula: see text] 0.05) as compared with the `none' group. There were no significant differences in the average RNFL values and total average GCC between the diabetes group and the `none' group. The values of FLV and GLV were significantly higher in the `glaucoma' group and the `both' group as compared with the `none' group. The foveal values were not significantly different across these four groups. Among the glaucoma cases, 25% were mild, 30% were moderate, and 45% were severe; there was no significant difference in the proportion of severity of glaucoma between the `glaucoma only' and `both' groups (p=0.32). After adjusting for severity and type of glaucoma, there were no statistically significant differences in the values of average RNFL (6.6, 95% CI: -1.9 to 15.2; P=0.13), total average GCC (3.6, -95% CI: -2.4 to 9.6; P=0.24), and GLV (-3.9, 95% CI: -9.5 to 1.6; P=0.16) in the `both group' as compared with the glaucoma only group. CONCLUSION: We found that diabetes with no DR did not significantly affect the retinal parameters in patients with glaucoma. Thus, it is less likely that thickness of these parameters will be overestimated in patients with glaucoma who have concurrent diabetes without retinopathy.
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spelling pubmed-98063042023-01-06 Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis Shah, Dhruven Dhamankar, Rita Shetty, Vijay Haldipurkar, Suhas S Chipade, Prakash Tanwar, Shabnam Sankhe, Prachi Venkatramani, Devendra Mhatre, Paresh Setia, Maninder Singh J Ophthalmic Vis Res Original Article PURPOSE: Presence of diabetes in glaucoma patients may influence findings while documenting the progression of glaucoma. We conducted the study to compare individual and combined effects of diabetes and glaucoma on macular thickness and ganglion cell complex thickness. METHODS: The present study is a cross-sectional analysis of 172 eyes of 114 individuals. The groups were categorized according to the following conditions: glaucoma, diabetes mellitus, both glaucoma and diabetes (`both' group), and none of these conditions (`none' group). Patients with diabetes did not have diabetic retinopathy (DR). We compared retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal loss of volume (FLV), and global loss of volume (GLV) among the groups. We used random effects multivariate analysis to adjust for potential confounders. RESULTS: The mean (SD) age of these individuals was 60.7 (10.1) years. The total average RNFL and GCC were significantly lower in the glaucoma group (RNFL: -36.27, 95% confidence intervals [CI]: -42.79 to -29.74; P [Formula: see text] 0.05, and GCC: -26.24, 95% CI: -31.49 to -20.98; P [Formula: see text] 0.05) and the `both' group (RNFL: -24.74, 95% CI: -32.84 to -16.63; P [Formula: see text] 0.05, and GCC: -17.92, 95% CI: -24.58 to -11.26; P [Formula: see text] 0.05) as compared with the `none' group. There were no significant differences in the average RNFL values and total average GCC between the diabetes group and the `none' group. The values of FLV and GLV were significantly higher in the `glaucoma' group and the `both' group as compared with the `none' group. The foveal values were not significantly different across these four groups. Among the glaucoma cases, 25% were mild, 30% were moderate, and 45% were severe; there was no significant difference in the proportion of severity of glaucoma between the `glaucoma only' and `both' groups (p=0.32). After adjusting for severity and type of glaucoma, there were no statistically significant differences in the values of average RNFL (6.6, 95% CI: -1.9 to 15.2; P=0.13), total average GCC (3.6, -95% CI: -2.4 to 9.6; P=0.24), and GLV (-3.9, 95% CI: -9.5 to 1.6; P=0.16) in the `both group' as compared with the glaucoma only group. CONCLUSION: We found that diabetes with no DR did not significantly affect the retinal parameters in patients with glaucoma. Thus, it is less likely that thickness of these parameters will be overestimated in patients with glaucoma who have concurrent diabetes without retinopathy. PUBLISHED BY KNOWLEDGE E 2022-11-29 /pmc/articles/PMC9806304/ /pubmed/36620706 http://dx.doi.org/10.18502/jovr.v17i4.12303 Text en Copyright © 2022 Shah et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shah, Dhruven
Dhamankar, Rita
Shetty, Vijay
Haldipurkar, Suhas S
Chipade, Prakash
Tanwar, Shabnam
Sankhe, Prachi
Venkatramani, Devendra
Mhatre, Paresh
Setia, Maninder Singh
Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis
title Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis
title_full Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis
title_fullStr Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis
title_full_unstemmed Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis
title_short Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis
title_sort individual and combined effects of diabetes and glaucoma on total macular thickness and ganglion cell complex thickness: a cross-sectional analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806304/
https://www.ncbi.nlm.nih.gov/pubmed/36620706
http://dx.doi.org/10.18502/jovr.v17i4.12303
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