A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion

The incidence of childhood central nervous system tumors in infants is about 6 per 100 000 children. Recent studies have showed recurrent fusion of the neurotrophic tyrosine receptor kinase (NTRK) gene in 10% of non-brainstem high grade glioma in very young children suggesting an oncogenic effect of...

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Detalles Bibliográficos
Autores principales: Garcia, Mekka R., Bell, Lena, Miller, Claire, Segal, Devorah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806371/
https://www.ncbi.nlm.nih.gov/pubmed/36601394
http://dx.doi.org/10.1177/2329048X221146982
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author Garcia, Mekka R.
Bell, Lena
Miller, Claire
Segal, Devorah
author_facet Garcia, Mekka R.
Bell, Lena
Miller, Claire
Segal, Devorah
author_sort Garcia, Mekka R.
collection PubMed
description The incidence of childhood central nervous system tumors in infants is about 6 per 100 000 children. Recent studies have showed recurrent fusion of the neurotrophic tyrosine receptor kinase (NTRK) gene in 10% of non-brainstem high grade glioma in very young children suggesting an oncogenic effect of the NTRK fusion genes. In this report, we present a rare, severe case of a full-term neonate who was noted to have widely splayed sutures and a bulging fontanelle at birth who was found to have infant-type hemispheric glioma with NTRK1 fusion with course complicated by seizures refractory to medical treatment. Patient was deemed a poor surgical candidate due to the size of the mass and thus parents opted for comfort care.
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spelling pubmed-98063712023-01-03 A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion Garcia, Mekka R. Bell, Lena Miller, Claire Segal, Devorah Child Neurol Open Case Report The incidence of childhood central nervous system tumors in infants is about 6 per 100 000 children. Recent studies have showed recurrent fusion of the neurotrophic tyrosine receptor kinase (NTRK) gene in 10% of non-brainstem high grade glioma in very young children suggesting an oncogenic effect of the NTRK fusion genes. In this report, we present a rare, severe case of a full-term neonate who was noted to have widely splayed sutures and a bulging fontanelle at birth who was found to have infant-type hemispheric glioma with NTRK1 fusion with course complicated by seizures refractory to medical treatment. Patient was deemed a poor surgical candidate due to the size of the mass and thus parents opted for comfort care. SAGE Publications 2022-12-22 /pmc/articles/PMC9806371/ /pubmed/36601394 http://dx.doi.org/10.1177/2329048X221146982 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Garcia, Mekka R.
Bell, Lena
Miller, Claire
Segal, Devorah
A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion
title A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion
title_full A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion
title_fullStr A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion
title_full_unstemmed A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion
title_short A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion
title_sort case of infant-type hemispheric glioma with ntrk1 fusion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806371/
https://www.ncbi.nlm.nih.gov/pubmed/36601394
http://dx.doi.org/10.1177/2329048X221146982
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