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Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels

Voltage-gated sodium channel (VGSC) activation is essential for action potential generation in the brain. Allosteric calcium-sensing receptor (CaSR) agonist, cinacalcet, strongly and ubiquitously inhibits VGSC currents in neocortical neurons via an unidentified, G-protein-dependent inhibitory molecu...

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Detalles Bibliográficos
Autores principales:	Lindner, Jamie S., Rajayer, Salil R., Martiszus, Briana J., Smith, Stephen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806421/ https://www.ncbi.nlm.nih.gov/pubmed/36601343 http://dx.doi.org/10.3389/fphys.2022.1066467

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