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The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer

Pancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is not an option for about 80%–85% of patients. F...

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Autores principales: Dong, Peng, Yan, Yu, Fan, Yujun, Wang, Hui, Wu, Danzhu, Yang, Liyuan, Zhang, Junpeng, Yin, Xiaoyang, Lv, Yajuan, Zhang, Jiandong, Hou, Yuzhu, Liu, Fengjun, Yu, Xinshuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806441/
https://www.ncbi.nlm.nih.gov/pubmed/36573015
http://dx.doi.org/10.1177/15330338221142472
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author Dong, Peng
Yan, Yu
Fan, Yujun
Wang, Hui
Wu, Danzhu
Yang, Liyuan
Zhang, Junpeng
Yin, Xiaoyang
Lv, Yajuan
Zhang, Jiandong
Hou, Yuzhu
Liu, Fengjun
Yu, Xinshuang
author_facet Dong, Peng
Yan, Yu
Fan, Yujun
Wang, Hui
Wu, Danzhu
Yang, Liyuan
Zhang, Junpeng
Yin, Xiaoyang
Lv, Yajuan
Zhang, Jiandong
Hou, Yuzhu
Liu, Fengjun
Yu, Xinshuang
author_sort Dong, Peng
collection PubMed
description Pancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is not an option for about 80%–85% of patients. For patients with inoperable pancreatic cancer, current conventional treatment modalities such as chemotherapy and radiotherapy (RT) have suboptimal efficacy. Tumor progression is closely associated with the tumor microenvironment, which includes peripheral blood vessels, bone marrow-derived inflammatory cells, fibroblasts, immune cells, signaling molecules, and extracellular matrix. Tumor cells affect the microenvironment by releasing extracellular signaling molecules, inducing peripheral immune tolerance, and promoting tumor angiogenesis. In turn, the immune cells of the tumor affect the survival and proliferation of cancer cells. Myeloid-derived suppressor cells are key cellular components in the tumor microenvironment and exert immunosuppressive functions by producing cytokines, recognizing other immune cells, and promoting tumor growth and metastasis. Myeloid-derived suppressor cells are the main regulator of the tumor immune response and a key target for tumor treatments. Since the combination of RT and immunotherapy is the main strategy for the treatment of pancreatic cancer, it is very important to understand the immune mechanisms which lead to MDSCs generation and the failure of current therapies in order to develop new target-based therapies. This review summarizes the research advances on the role of Myeloid-derived suppressor cells in the progression of pancreatic cancer and its treatment application in recent years.
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spelling pubmed-98064412023-01-03 The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer Dong, Peng Yan, Yu Fan, Yujun Wang, Hui Wu, Danzhu Yang, Liyuan Zhang, Junpeng Yin, Xiaoyang Lv, Yajuan Zhang, Jiandong Hou, Yuzhu Liu, Fengjun Yu, Xinshuang Technol Cancer Res Treat Screening, Diagnosis, and Treatment of Pancreatic Cancer Pancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is not an option for about 80%–85% of patients. For patients with inoperable pancreatic cancer, current conventional treatment modalities such as chemotherapy and radiotherapy (RT) have suboptimal efficacy. Tumor progression is closely associated with the tumor microenvironment, which includes peripheral blood vessels, bone marrow-derived inflammatory cells, fibroblasts, immune cells, signaling molecules, and extracellular matrix. Tumor cells affect the microenvironment by releasing extracellular signaling molecules, inducing peripheral immune tolerance, and promoting tumor angiogenesis. In turn, the immune cells of the tumor affect the survival and proliferation of cancer cells. Myeloid-derived suppressor cells are key cellular components in the tumor microenvironment and exert immunosuppressive functions by producing cytokines, recognizing other immune cells, and promoting tumor growth and metastasis. Myeloid-derived suppressor cells are the main regulator of the tumor immune response and a key target for tumor treatments. Since the combination of RT and immunotherapy is the main strategy for the treatment of pancreatic cancer, it is very important to understand the immune mechanisms which lead to MDSCs generation and the failure of current therapies in order to develop new target-based therapies. This review summarizes the research advances on the role of Myeloid-derived suppressor cells in the progression of pancreatic cancer and its treatment application in recent years. SAGE Publications 2022-12-26 /pmc/articles/PMC9806441/ /pubmed/36573015 http://dx.doi.org/10.1177/15330338221142472 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Screening, Diagnosis, and Treatment of Pancreatic Cancer
Dong, Peng
Yan, Yu
Fan, Yujun
Wang, Hui
Wu, Danzhu
Yang, Liyuan
Zhang, Junpeng
Yin, Xiaoyang
Lv, Yajuan
Zhang, Jiandong
Hou, Yuzhu
Liu, Fengjun
Yu, Xinshuang
The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer
title The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer
title_full The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer
title_fullStr The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer
title_full_unstemmed The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer
title_short The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer
title_sort role of myeloid-derived suppressor cells in the treatment of pancreatic cancer
topic Screening, Diagnosis, and Treatment of Pancreatic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806441/
https://www.ncbi.nlm.nih.gov/pubmed/36573015
http://dx.doi.org/10.1177/15330338221142472
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