Cargando…
Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease
In this conceptual analysis, we present our concepts on two issues regarding autoimmune bullous diseases (AIBD), namely (i) current nomenclature of AIBD requires updating by incorporating molecular data and (ii) pemphigus vulgaris (PV) “likes” areas adjacent to natural body orifices. The problem of...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806572/ https://www.ncbi.nlm.nih.gov/pubmed/36601117 http://dx.doi.org/10.3389/fimmu.2022.1103375 |
_version_ | 1784862560346963968 |
---|---|
author | Dmochowski, Marian Jałowska, Magdalena Bowszyc-Dmochowska, Monika |
author_facet | Dmochowski, Marian Jałowska, Magdalena Bowszyc-Dmochowska, Monika |
author_sort | Dmochowski, Marian |
collection | PubMed |
description | In this conceptual analysis, we present our concepts on two issues regarding autoimmune bullous diseases (AIBD), namely (i) current nomenclature of AIBD requires updating by incorporating molecular data and (ii) pemphigus vulgaris (PV) “likes” areas adjacent to natural body orifices. The problem of inadequacy of the currently used nomenclature was noticed recently by Zillikens, who proposed to form a group with the task of updating it. The early efforts by Dmochowski to update this nomenclature happened to be a daunting task. Nevertheless, the ideal nomenclature should retain the bulk of clinical data, which generations of dermatologists are accustomed to, including triggers if known, and incorporate molecular data revealing targets of autoimmune response and immunoglobulin isotypes involved. The natural body orifices affected by PV were previously described in numerous publications. However, these openings are described separately in these publications. Here, Dmochowski comes up with an intellectual concept that this propensity of PV unifies seemingly diverse clinical features of this disease. |
format | Online Article Text |
id | pubmed-9806572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98065722023-01-03 Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease Dmochowski, Marian Jałowska, Magdalena Bowszyc-Dmochowska, Monika Front Immunol Immunology In this conceptual analysis, we present our concepts on two issues regarding autoimmune bullous diseases (AIBD), namely (i) current nomenclature of AIBD requires updating by incorporating molecular data and (ii) pemphigus vulgaris (PV) “likes” areas adjacent to natural body orifices. The problem of inadequacy of the currently used nomenclature was noticed recently by Zillikens, who proposed to form a group with the task of updating it. The early efforts by Dmochowski to update this nomenclature happened to be a daunting task. Nevertheless, the ideal nomenclature should retain the bulk of clinical data, which generations of dermatologists are accustomed to, including triggers if known, and incorporate molecular data revealing targets of autoimmune response and immunoglobulin isotypes involved. The natural body orifices affected by PV were previously described in numerous publications. However, these openings are described separately in these publications. Here, Dmochowski comes up with an intellectual concept that this propensity of PV unifies seemingly diverse clinical features of this disease. Frontiers Media S.A. 2022-12-19 /pmc/articles/PMC9806572/ /pubmed/36601117 http://dx.doi.org/10.3389/fimmu.2022.1103375 Text en Copyright © 2022 Dmochowski, Jałowska and Bowszyc-Dmochowska https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Dmochowski, Marian Jałowska, Magdalena Bowszyc-Dmochowska, Monika Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease |
title | Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease |
title_full | Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease |
title_fullStr | Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease |
title_full_unstemmed | Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease |
title_short | Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease |
title_sort | issues occupying our minds: nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806572/ https://www.ncbi.nlm.nih.gov/pubmed/36601117 http://dx.doi.org/10.3389/fimmu.2022.1103375 |
work_keys_str_mv | AT dmochowskimarian issuesoccupyingourmindsnomenclatureofautoimmuneblisteringdiseasesrequiresupdatingpemphigusvulgarispropensitytoaffectareasadjacenttonaturalbodyorificesunifiesseeminglydiverseclinicalfeaturesofthisdisease AT jałowskamagdalena issuesoccupyingourmindsnomenclatureofautoimmuneblisteringdiseasesrequiresupdatingpemphigusvulgarispropensitytoaffectareasadjacenttonaturalbodyorificesunifiesseeminglydiverseclinicalfeaturesofthisdisease AT bowszycdmochowskamonika issuesoccupyingourmindsnomenclatureofautoimmuneblisteringdiseasesrequiresupdatingpemphigusvulgarispropensitytoaffectareasadjacenttonaturalbodyorificesunifiesseeminglydiverseclinicalfeaturesofthisdisease |