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Epigenetic nature of Arabidopsis thaliana telomeres
The epigenetic features of defined chromosomal domains condition their biochemical and functional properties. Therefore, there is considerable interest in studying the epigenetic marks present at relevant chromosomal loci. Telomeric regions, which include telomeres and subtelomeres, have been tradit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806604/ https://www.ncbi.nlm.nih.gov/pubmed/36218957 http://dx.doi.org/10.1093/plphys/kiac471 |
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author | Vaquero-Sedas, María I Vega-Palas, Miguel A |
author_facet | Vaquero-Sedas, María I Vega-Palas, Miguel A |
author_sort | Vaquero-Sedas, María I |
collection | PubMed |
description | The epigenetic features of defined chromosomal domains condition their biochemical and functional properties. Therefore, there is considerable interest in studying the epigenetic marks present at relevant chromosomal loci. Telomeric regions, which include telomeres and subtelomeres, have been traditionally considered heterochromatic. However, whereas the heterochromatic nature of subtelomeres has been widely accepted, the epigenetic status of telomeres remains controversial. Here, we studied the epigenetic features of Arabidopsis (Arabidopsis thaliana) telomeres by analyzing multiple genome-wide ChIP-seq experiments. Our analyses revealed that Arabidopsis telomeres are not significantly enriched either in euchromatic marks like H3K4me2, H3K9ac, and H3K27me3 or in heterochromatic marks such as H3K27me1 and H3K9me2. Thus, telomeric regions in Arabidopsis have a bimodal chromatin organization with telomeres lacking significant levels of canonical euchromatic and heterochromatic marks followed by heterochromatic subtelomeres. Since heterochromatin is known to influence telomere function, the heterochromatic modifications present at Arabidopsis subtelomeres could play a relevant role in telomere biology. |
format | Online Article Text |
id | pubmed-9806604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98066042023-01-03 Epigenetic nature of Arabidopsis thaliana telomeres Vaquero-Sedas, María I Vega-Palas, Miguel A Plant Physiol Research Report The epigenetic features of defined chromosomal domains condition their biochemical and functional properties. Therefore, there is considerable interest in studying the epigenetic marks present at relevant chromosomal loci. Telomeric regions, which include telomeres and subtelomeres, have been traditionally considered heterochromatic. However, whereas the heterochromatic nature of subtelomeres has been widely accepted, the epigenetic status of telomeres remains controversial. Here, we studied the epigenetic features of Arabidopsis (Arabidopsis thaliana) telomeres by analyzing multiple genome-wide ChIP-seq experiments. Our analyses revealed that Arabidopsis telomeres are not significantly enriched either in euchromatic marks like H3K4me2, H3K9ac, and H3K27me3 or in heterochromatic marks such as H3K27me1 and H3K9me2. Thus, telomeric regions in Arabidopsis have a bimodal chromatin organization with telomeres lacking significant levels of canonical euchromatic and heterochromatic marks followed by heterochromatic subtelomeres. Since heterochromatin is known to influence telomere function, the heterochromatic modifications present at Arabidopsis subtelomeres could play a relevant role in telomere biology. Oxford University Press 2022-10-11 /pmc/articles/PMC9806604/ /pubmed/36218957 http://dx.doi.org/10.1093/plphys/kiac471 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of American Society of Plant Biologists. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Report Vaquero-Sedas, María I Vega-Palas, Miguel A Epigenetic nature of Arabidopsis thaliana telomeres |
title | Epigenetic nature of Arabidopsis thaliana telomeres |
title_full | Epigenetic nature of Arabidopsis thaliana telomeres |
title_fullStr | Epigenetic nature of Arabidopsis thaliana telomeres |
title_full_unstemmed | Epigenetic nature of Arabidopsis thaliana telomeres |
title_short | Epigenetic nature of Arabidopsis thaliana telomeres |
title_sort | epigenetic nature of arabidopsis thaliana telomeres |
topic | Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806604/ https://www.ncbi.nlm.nih.gov/pubmed/36218957 http://dx.doi.org/10.1093/plphys/kiac471 |
work_keys_str_mv | AT vaquerosedasmariai epigeneticnatureofarabidopsisthalianatelomeres AT vegapalasmiguela epigeneticnatureofarabidopsisthalianatelomeres |