A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time

BACKGROUND: (p-BthTX-I)(2) K, a dimeric analog peptide derived from the C-terminal region of phospholipase A2-like bothropstoxin-I (p-BthTX-I), is resistant to plasma proteolysis and inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains with weak cytotoxic effects. Complicati...

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Detalles Bibliográficos
Autores principales: Nogueira, Ruben Siedlarczyk, Salu, Bruno Ramos, Nardelli, Vinícius Goulart, Bonturi, Camila Ramalho, Pereira, Marina Rodrigues, de Abreu Maffei, Francisco Humberto, Cilli, Eduardo Maffud, Oliva, Maria Luiza Vilela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806807/
https://www.ncbi.nlm.nih.gov/pubmed/36593467
http://dx.doi.org/10.1186/s12959-022-00436-5

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