Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence

Cancer cells encounter a hostile tumor microenvironment (TME), and their adaptations to metabolic stresses determine metastatic competence. Here, we show that the metabolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) is induced in hypoxic tumors acquiring metabolic plastici...

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Detalles Bibliográficos
Autores principales: Dai, Tao, Rosario, Spencer R., Katsuta, Eriko, Dessai, Abhisha Sawant, Paterson, Emily J., Novickis, Aaron T., Cortes Gomez, Eduardo, Zhu, Bokai, Liu, Song, Wang, Hai, Abrams, Scott I., Seshadri, Mukund, Bshara, Wiam, Dasgupta, Subhamoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807018/
https://www.ncbi.nlm.nih.gov/pubmed/36476868
http://dx.doi.org/10.1016/j.celrep.2022.111756

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