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Acute Retinal Pigment Epitheliitis following Vaccination

We present a rare case of acute retinal pigment epitheliitis (ARPE) following vaccination. An 18-year-old Japanese man visited our hospital with a 5-day history of a central scotoma in the right eye. He had received the second dose of coronavirus disease 2019 vaccination (BNT162b2 mRNA, Pfizer-BioNT...

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Autores principales: Sasajima, Hirofumi, Zako, Masahiro, Aoyagi, Akari, Ueta, Yoshiki, Suzuki, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807051/
https://www.ncbi.nlm.nih.gov/pubmed/36601646
http://dx.doi.org/10.1159/000527598
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author Sasajima, Hirofumi
Zako, Masahiro
Aoyagi, Akari
Ueta, Yoshiki
Suzuki, Takafumi
author_facet Sasajima, Hirofumi
Zako, Masahiro
Aoyagi, Akari
Ueta, Yoshiki
Suzuki, Takafumi
author_sort Sasajima, Hirofumi
collection PubMed
description We present a rare case of acute retinal pigment epitheliitis (ARPE) following vaccination. An 18-year-old Japanese man visited our hospital with a 5-day history of a central scotoma in the right eye. He had received the second dose of coronavirus disease 2019 vaccination (BNT162b2 mRNA, Pfizer-BioNTech) 1 month prior, following which he developed a low-grade fever of 37.3–37.5°C for 2 days accompanied by joint pain. Although he had received influenza vaccination 5 days prior to this presentation, no systemic symptoms other than injection site pain were observed. Blood test results were unremarkable. Ophthalmological examination revealed a decimal best-corrected visual acuity (BCVA) of 0.8 and 1.2 in the right and left eyes, respectively. Intraocular pressure was 15 mm Hg in both eyes. Intraocular inflammation was not observed. Fundus examination revealed a localized lesion of pigment stippling associated with yellowish hypopigmentation in the fovea. Fluorescein angiography revealed slight transmission hyperfluorescence without leakage. Optical coherence tomography (OCT) revealed disruption of the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ). We diagnosed the patient with ARPE in the right eye. The patient was followed up without treatment. Five weeks after onset, the central scotoma in the right eye disappeared, and patient’s BCVA in the right eye improved to 1.5. OCT showed improvement in ELM and EZ continuity in the right eye, but IZ remained disruptive. Although the exact pathophysiology of the association between ARPE and these vaccinations is unclear, ARPE may develop after the vaccination.
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spelling pubmed-98070512023-01-03 Acute Retinal Pigment Epitheliitis following Vaccination Sasajima, Hirofumi Zako, Masahiro Aoyagi, Akari Ueta, Yoshiki Suzuki, Takafumi Case Rep Ophthalmol Case Report We present a rare case of acute retinal pigment epitheliitis (ARPE) following vaccination. An 18-year-old Japanese man visited our hospital with a 5-day history of a central scotoma in the right eye. He had received the second dose of coronavirus disease 2019 vaccination (BNT162b2 mRNA, Pfizer-BioNTech) 1 month prior, following which he developed a low-grade fever of 37.3–37.5°C for 2 days accompanied by joint pain. Although he had received influenza vaccination 5 days prior to this presentation, no systemic symptoms other than injection site pain were observed. Blood test results were unremarkable. Ophthalmological examination revealed a decimal best-corrected visual acuity (BCVA) of 0.8 and 1.2 in the right and left eyes, respectively. Intraocular pressure was 15 mm Hg in both eyes. Intraocular inflammation was not observed. Fundus examination revealed a localized lesion of pigment stippling associated with yellowish hypopigmentation in the fovea. Fluorescein angiography revealed slight transmission hyperfluorescence without leakage. Optical coherence tomography (OCT) revealed disruption of the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ). We diagnosed the patient with ARPE in the right eye. The patient was followed up without treatment. Five weeks after onset, the central scotoma in the right eye disappeared, and patient’s BCVA in the right eye improved to 1.5. OCT showed improvement in ELM and EZ continuity in the right eye, but IZ remained disruptive. Although the exact pathophysiology of the association between ARPE and these vaccinations is unclear, ARPE may develop after the vaccination. The Author(s). Published by S. Karger AG 2022-11-10 /pmc/articles/PMC9807051/ /pubmed/36601646 http://dx.doi.org/10.1159/000527598 Text en © 2022 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Sasajima, Hirofumi
Zako, Masahiro
Aoyagi, Akari
Ueta, Yoshiki
Suzuki, Takafumi
Acute Retinal Pigment Epitheliitis following Vaccination
title Acute Retinal Pigment Epitheliitis following Vaccination
title_full Acute Retinal Pigment Epitheliitis following Vaccination
title_fullStr Acute Retinal Pigment Epitheliitis following Vaccination
title_full_unstemmed Acute Retinal Pigment Epitheliitis following Vaccination
title_short Acute Retinal Pigment Epitheliitis following Vaccination
title_sort acute retinal pigment epitheliitis following vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807051/
https://www.ncbi.nlm.nih.gov/pubmed/36601646
http://dx.doi.org/10.1159/000527598
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