New mechanism of metformin action mediated by lysosomal presenilin enhancer 2

Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation and activation of AMPK.[Image: see text]

Detalles Bibliográficos
Autores principales: Sugawara, Kenji, Ogawa, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807141/
https://www.ncbi.nlm.nih.gov/pubmed/36308027
http://dx.doi.org/10.1111/jdi.13925
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author Sugawara, Kenji
Ogawa, Wataru
author_facet Sugawara, Kenji
Ogawa, Wataru
author_sort Sugawara, Kenji
collection PubMed
description Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation and activation of AMPK.[Image: see text]
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spelling pubmed-98071412023-01-04 New mechanism of metformin action mediated by lysosomal presenilin enhancer 2 Sugawara, Kenji Ogawa, Wataru J Diabetes Investig Commentary Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation and activation of AMPK.[Image: see text] John Wiley and Sons Inc. 2022-10-28 /pmc/articles/PMC9807141/ /pubmed/36308027 http://dx.doi.org/10.1111/jdi.13925 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentary
Sugawara, Kenji
Ogawa, Wataru
New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
title New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
title_full New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
title_fullStr New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
title_full_unstemmed New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
title_short New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
title_sort new mechanism of metformin action mediated by lysosomal presenilin enhancer 2
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807141/
https://www.ncbi.nlm.nih.gov/pubmed/36308027
http://dx.doi.org/10.1111/jdi.13925
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