Cargando…
New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation and activation of AMPK.[Image: see text]
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807141/ https://www.ncbi.nlm.nih.gov/pubmed/36308027 http://dx.doi.org/10.1111/jdi.13925 |