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Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease
INTRODUCTION: The role of endogenous androgens in kidney function and disease has not been extensively explored in men and women. RESEARCH DESIGN AND METHODS: We analyzed data from the observational KORA F4 study and its follow-up examination KORA FF4 (median follow-up time 6.5 years) including 1293...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807167/ https://www.ncbi.nlm.nih.gov/pubmed/36601008 http://dx.doi.org/10.3389/fendo.2022.1000650 |
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author | Lau, Lina Hui Ying Nano, Jana Prehn, Cornelia Cecil, Alexander Rathmann, Wolfgang Zeller, Tanja Lechner, Andreas Adamski, Jerzy Peters, Annette Thorand, Barbara |
author_facet | Lau, Lina Hui Ying Nano, Jana Prehn, Cornelia Cecil, Alexander Rathmann, Wolfgang Zeller, Tanja Lechner, Andreas Adamski, Jerzy Peters, Annette Thorand, Barbara |
author_sort | Lau, Lina Hui Ying |
collection | PubMed |
description | INTRODUCTION: The role of endogenous androgens in kidney function and disease has not been extensively explored in men and women. RESEARCH DESIGN AND METHODS: We analyzed data from the observational KORA F4 study and its follow-up examination KORA FF4 (median follow-up time 6.5 years) including 1293 men and 650 peri- and postmenopausal women, not using exogenous sex hormones. We examined the associations between endogenous androgens (testosterone [T], dihydrotestosterone [DHT], free T [fT], free DHT [fDHT], and T/DHT), with estimated glomerular filtration rate (eGFR) at baseline and follow-up, prevalent, and incident chronic kidney disease (CKD) adjusting for common CKD risk factors. RESULTS: At baseline, 73 men (5.7%) and 54 women (8.4%) had prevalent CKD. Cross-sectionally, no significant associations between androgens and kidney function were observed among men. In women, elevated T (β=-1.305, [95% CI -2.290; -0.320]) and fT (β=-1.423, [95% CI -2.449; -0.397]) were associated with lower eGFR. Prospectively, 81 men (8.8%) and 60 women (15.2%) developed incident CKD. In women, a reverse J-shaped associations was observed between DHT and incident CKD (P(non-linear)=0.029), while higher fDHT was associated with lower incident CKD risk (odds ratio per 1 standard deviation=0.613, [95% CI 0.369; 0.971]. Among men, T/DHT (β=-0.819, [95% CI -1.413; -0.226]) and SHBG (P(non-linear)=0.011) were associated with eGFR at follow-up but not with incident CKD. Some associations appeared to be modified by type 2 diabetes (T2D). CONCLUSION: Suggestive associations are observed of androgens and SHBG with kidney impairment among men and women. However, larger well-phenotyped prospective studies are required to further elucidate the potential of androgens, SHBG, and T2D as modifiable risk factors for kidney function and CKD. |
format | Online Article Text |
id | pubmed-9807167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98071672023-01-03 Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease Lau, Lina Hui Ying Nano, Jana Prehn, Cornelia Cecil, Alexander Rathmann, Wolfgang Zeller, Tanja Lechner, Andreas Adamski, Jerzy Peters, Annette Thorand, Barbara Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: The role of endogenous androgens in kidney function and disease has not been extensively explored in men and women. RESEARCH DESIGN AND METHODS: We analyzed data from the observational KORA F4 study and its follow-up examination KORA FF4 (median follow-up time 6.5 years) including 1293 men and 650 peri- and postmenopausal women, not using exogenous sex hormones. We examined the associations between endogenous androgens (testosterone [T], dihydrotestosterone [DHT], free T [fT], free DHT [fDHT], and T/DHT), with estimated glomerular filtration rate (eGFR) at baseline and follow-up, prevalent, and incident chronic kidney disease (CKD) adjusting for common CKD risk factors. RESULTS: At baseline, 73 men (5.7%) and 54 women (8.4%) had prevalent CKD. Cross-sectionally, no significant associations between androgens and kidney function were observed among men. In women, elevated T (β=-1.305, [95% CI -2.290; -0.320]) and fT (β=-1.423, [95% CI -2.449; -0.397]) were associated with lower eGFR. Prospectively, 81 men (8.8%) and 60 women (15.2%) developed incident CKD. In women, a reverse J-shaped associations was observed between DHT and incident CKD (P(non-linear)=0.029), while higher fDHT was associated with lower incident CKD risk (odds ratio per 1 standard deviation=0.613, [95% CI 0.369; 0.971]. Among men, T/DHT (β=-0.819, [95% CI -1.413; -0.226]) and SHBG (P(non-linear)=0.011) were associated with eGFR at follow-up but not with incident CKD. Some associations appeared to be modified by type 2 diabetes (T2D). CONCLUSION: Suggestive associations are observed of androgens and SHBG with kidney impairment among men and women. However, larger well-phenotyped prospective studies are required to further elucidate the potential of androgens, SHBG, and T2D as modifiable risk factors for kidney function and CKD. Frontiers Media S.A. 2022-12-19 /pmc/articles/PMC9807167/ /pubmed/36601008 http://dx.doi.org/10.3389/fendo.2022.1000650 Text en Copyright © 2022 Lau, Nano, Prehn, Cecil, Rathmann, Zeller, Lechner, Adamski, Peters and Thorand https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Lau, Lina Hui Ying Nano, Jana Prehn, Cornelia Cecil, Alexander Rathmann, Wolfgang Zeller, Tanja Lechner, Andreas Adamski, Jerzy Peters, Annette Thorand, Barbara Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease |
title | Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease |
title_full | Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease |
title_fullStr | Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease |
title_full_unstemmed | Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease |
title_short | Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease |
title_sort | associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807167/ https://www.ncbi.nlm.nih.gov/pubmed/36601008 http://dx.doi.org/10.3389/fendo.2022.1000650 |
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