Cold shock protein RBM3 is upregulated in the autophagy-deficient brain

Neural autophagy plays an important role in regulating protein quality control, brain homeostasis, and body temperature. However, the mechanism that links a defect in autophagy to body temperature has not been elucidated. Here, we report that RNA binding motif protein 3 (RBM3) is a potential candida...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakamura, Junnosuke, Aihara, Takuma, Chiba, Tomoki, Tsuruta, Fuminori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807172/
https://www.ncbi.nlm.nih.gov/pubmed/36601325
http://dx.doi.org/10.17912/micropub.biology.000695
_version_ 1784862663289864192
author Nakamura, Junnosuke
Aihara, Takuma
Chiba, Tomoki
Tsuruta, Fuminori
author_facet Nakamura, Junnosuke
Aihara, Takuma
Chiba, Tomoki
Tsuruta, Fuminori
author_sort Nakamura, Junnosuke
collection PubMed
description Neural autophagy plays an important role in regulating protein quality control, brain homeostasis, and body temperature. However, the mechanism that links a defect in autophagy to body temperature has not been elucidated. Here, we report that RNA binding motif protein 3 (RBM3) is a potential candidate that regulates body temperature. We found that the body temperatures of Nestin-Cre ; Atg7 (f/f) conditional KO (cKO) mice were lower than that of wild-type (WT) mice. Moreover, RBM3 was upregulated in the Nestin-Cre ; Atg7 (f/f) brain. These data suggest that RBM3 is an implicit target that maintains body temperature influenced by neural autophagy.
format Online
Article
Text
id pubmed-9807172
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Caltech Library
record_format MEDLINE/PubMed
spelling pubmed-98071722023-01-03 Cold shock protein RBM3 is upregulated in the autophagy-deficient brain Nakamura, Junnosuke Aihara, Takuma Chiba, Tomoki Tsuruta, Fuminori MicroPubl Biol New Finding Neural autophagy plays an important role in regulating protein quality control, brain homeostasis, and body temperature. However, the mechanism that links a defect in autophagy to body temperature has not been elucidated. Here, we report that RNA binding motif protein 3 (RBM3) is a potential candidate that regulates body temperature. We found that the body temperatures of Nestin-Cre ; Atg7 (f/f) conditional KO (cKO) mice were lower than that of wild-type (WT) mice. Moreover, RBM3 was upregulated in the Nestin-Cre ; Atg7 (f/f) brain. These data suggest that RBM3 is an implicit target that maintains body temperature influenced by neural autophagy. Caltech Library 2022-12-08 /pmc/articles/PMC9807172/ /pubmed/36601325 http://dx.doi.org/10.17912/micropub.biology.000695 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Nakamura, Junnosuke
Aihara, Takuma
Chiba, Tomoki
Tsuruta, Fuminori
Cold shock protein RBM3 is upregulated in the autophagy-deficient brain
title Cold shock protein RBM3 is upregulated in the autophagy-deficient brain
title_full Cold shock protein RBM3 is upregulated in the autophagy-deficient brain
title_fullStr Cold shock protein RBM3 is upregulated in the autophagy-deficient brain
title_full_unstemmed Cold shock protein RBM3 is upregulated in the autophagy-deficient brain
title_short Cold shock protein RBM3 is upregulated in the autophagy-deficient brain
title_sort cold shock protein rbm3 is upregulated in the autophagy-deficient brain
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807172/
https://www.ncbi.nlm.nih.gov/pubmed/36601325
http://dx.doi.org/10.17912/micropub.biology.000695
work_keys_str_mv AT nakamurajunnosuke coldshockproteinrbm3isupregulatedintheautophagydeficientbrain
AT aiharatakuma coldshockproteinrbm3isupregulatedintheautophagydeficientbrain
AT chibatomoki coldshockproteinrbm3isupregulatedintheautophagydeficientbrain
AT tsurutafuminori coldshockproteinrbm3isupregulatedintheautophagydeficientbrain

Ejemplares similares