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Association Between Vitamin D and Minor Salivary Gland Inflammation
Objective There has been increasing research regarding the effects of vitamin D on autoimmune disorders. There is some evidence of a correlation between vitamin D levels and sicca symptoms. We attempted to evaluate the correlation between vitamin D levels and inflammation of the minor salivary gland...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807185/ https://www.ncbi.nlm.nih.gov/pubmed/36601215 http://dx.doi.org/10.7759/cureus.32160 |
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author | Mehta, Vivek Peredo-Wende, Ruben |
author_facet | Mehta, Vivek Peredo-Wende, Ruben |
author_sort | Mehta, Vivek |
collection | PubMed |
description | Objective There has been increasing research regarding the effects of vitamin D on autoimmune disorders. There is some evidence of a correlation between vitamin D levels and sicca symptoms. We attempted to evaluate the correlation between vitamin D levels and inflammation of the minor salivary gland (MSG). Methods Data for 214 patients who had undergone MSG biopsy were reviewed. Eighteen patients with other autoimmune/neoplastic processes were excluded. Seventy-seven of 196 patients had serum Vitamin D levels available and were selected for this retrospective study. Demographic, clinical, and immunological features, extra-glandular manifestations, autoantibodies, and clinical laboratory tests were collected and compared between patient groups with a focus score (FS) of 0 and 1 or more. Results Out of 77, 29 patients had an FS of 0 while 48 had an FS of 1 or more. Mean vitamin D levels were noted to be lower in patients with an FS of 1 when compared to patients with an FS of 1 or more. Conclusion In this study, patients with an FS of 1 were noted to have low vitamin D levels but this association was not seen at a higher FS. |
format | Online Article Text |
id | pubmed-9807185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-98071852023-01-03 Association Between Vitamin D and Minor Salivary Gland Inflammation Mehta, Vivek Peredo-Wende, Ruben Cureus Rheumatology Objective There has been increasing research regarding the effects of vitamin D on autoimmune disorders. There is some evidence of a correlation between vitamin D levels and sicca symptoms. We attempted to evaluate the correlation between vitamin D levels and inflammation of the minor salivary gland (MSG). Methods Data for 214 patients who had undergone MSG biopsy were reviewed. Eighteen patients with other autoimmune/neoplastic processes were excluded. Seventy-seven of 196 patients had serum Vitamin D levels available and were selected for this retrospective study. Demographic, clinical, and immunological features, extra-glandular manifestations, autoantibodies, and clinical laboratory tests were collected and compared between patient groups with a focus score (FS) of 0 and 1 or more. Results Out of 77, 29 patients had an FS of 0 while 48 had an FS of 1 or more. Mean vitamin D levels were noted to be lower in patients with an FS of 1 when compared to patients with an FS of 1 or more. Conclusion In this study, patients with an FS of 1 were noted to have low vitamin D levels but this association was not seen at a higher FS. Cureus 2022-12-03 /pmc/articles/PMC9807185/ /pubmed/36601215 http://dx.doi.org/10.7759/cureus.32160 Text en Copyright © 2022, Mehta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Rheumatology Mehta, Vivek Peredo-Wende, Ruben Association Between Vitamin D and Minor Salivary Gland Inflammation |
title | Association Between Vitamin D and Minor Salivary Gland Inflammation |
title_full | Association Between Vitamin D and Minor Salivary Gland Inflammation |
title_fullStr | Association Between Vitamin D and Minor Salivary Gland Inflammation |
title_full_unstemmed | Association Between Vitamin D and Minor Salivary Gland Inflammation |
title_short | Association Between Vitamin D and Minor Salivary Gland Inflammation |
title_sort | association between vitamin d and minor salivary gland inflammation |
topic | Rheumatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807185/ https://www.ncbi.nlm.nih.gov/pubmed/36601215 http://dx.doi.org/10.7759/cureus.32160 |
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