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Association Between Vitamin D and Minor Salivary Gland Inflammation

Objective There has been increasing research regarding the effects of vitamin D on autoimmune disorders. There is some evidence of a correlation between vitamin D levels and sicca symptoms. We attempted to evaluate the correlation between vitamin D levels and inflammation of the minor salivary gland...

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Autores principales: Mehta, Vivek, Peredo-Wende, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807185/
https://www.ncbi.nlm.nih.gov/pubmed/36601215
http://dx.doi.org/10.7759/cureus.32160
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author Mehta, Vivek
Peredo-Wende, Ruben
author_facet Mehta, Vivek
Peredo-Wende, Ruben
author_sort Mehta, Vivek
collection PubMed
description Objective There has been increasing research regarding the effects of vitamin D on autoimmune disorders. There is some evidence of a correlation between vitamin D levels and sicca symptoms. We attempted to evaluate the correlation between vitamin D levels and inflammation of the minor salivary gland (MSG). Methods Data for 214 patients who had undergone MSG biopsy were reviewed. Eighteen patients with other autoimmune/neoplastic processes were excluded. Seventy-seven of 196 patients had serum Vitamin D levels available and were selected for this retrospective study. Demographic, clinical, and immunological features, extra-glandular manifestations, autoantibodies, and clinical laboratory tests were collected and compared between patient groups with a focus score (FS) of 0 and 1 or more. Results Out of 77, 29 patients had an FS of 0 while 48 had an FS of 1 or more. Mean vitamin D levels were noted to be lower in patients with an FS of 1 when compared to patients with an FS of 1 or more. Conclusion In this study, patients with an FS of 1 were noted to have low vitamin D levels but this association was not seen at a higher FS.
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spelling pubmed-98071852023-01-03 Association Between Vitamin D and Minor Salivary Gland Inflammation Mehta, Vivek Peredo-Wende, Ruben Cureus Rheumatology Objective There has been increasing research regarding the effects of vitamin D on autoimmune disorders. There is some evidence of a correlation between vitamin D levels and sicca symptoms. We attempted to evaluate the correlation between vitamin D levels and inflammation of the minor salivary gland (MSG). Methods Data for 214 patients who had undergone MSG biopsy were reviewed. Eighteen patients with other autoimmune/neoplastic processes were excluded. Seventy-seven of 196 patients had serum Vitamin D levels available and were selected for this retrospective study. Demographic, clinical, and immunological features, extra-glandular manifestations, autoantibodies, and clinical laboratory tests were collected and compared between patient groups with a focus score (FS) of 0 and 1 or more. Results Out of 77, 29 patients had an FS of 0 while 48 had an FS of 1 or more. Mean vitamin D levels were noted to be lower in patients with an FS of 1 when compared to patients with an FS of 1 or more. Conclusion In this study, patients with an FS of 1 were noted to have low vitamin D levels but this association was not seen at a higher FS. Cureus 2022-12-03 /pmc/articles/PMC9807185/ /pubmed/36601215 http://dx.doi.org/10.7759/cureus.32160 Text en Copyright © 2022, Mehta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Rheumatology
Mehta, Vivek
Peredo-Wende, Ruben
Association Between Vitamin D and Minor Salivary Gland Inflammation
title Association Between Vitamin D and Minor Salivary Gland Inflammation
title_full Association Between Vitamin D and Minor Salivary Gland Inflammation
title_fullStr Association Between Vitamin D and Minor Salivary Gland Inflammation
title_full_unstemmed Association Between Vitamin D and Minor Salivary Gland Inflammation
title_short Association Between Vitamin D and Minor Salivary Gland Inflammation
title_sort association between vitamin d and minor salivary gland inflammation
topic Rheumatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807185/
https://www.ncbi.nlm.nih.gov/pubmed/36601215
http://dx.doi.org/10.7759/cureus.32160
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