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Mortality audit of COVID-19 infection among children

BACKGROUND & OBJECTIVES: As severe COVID-19 and mortality are not common in children, there is a scarcity of data regarding the cause of mortality in children infected with SARS-CoV-2. This study was aimed to describe the all-cause mortality and COVID-19 death (disease-specific mortality) in chi...

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Autores principales: Sharma, Raman, Agarwal, Ashish, Ranjan, Ankit, Jayashree, Muralidharan, Kumar, Praveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807188/
https://www.ncbi.nlm.nih.gov/pubmed/36124499
http://dx.doi.org/10.4103/ijmr.ijmr_2500_21
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author Sharma, Raman
Agarwal, Ashish
Ranjan, Ankit
Jayashree, Muralidharan
Kumar, Praveen
author_facet Sharma, Raman
Agarwal, Ashish
Ranjan, Ankit
Jayashree, Muralidharan
Kumar, Praveen
author_sort Sharma, Raman
collection PubMed
description BACKGROUND & OBJECTIVES: As severe COVID-19 and mortality are not common in children, there is a scarcity of data regarding the cause of mortality in children infected with SARS-CoV-2. This study was aimed to describe the all-cause mortality and COVID-19 death (disease-specific mortality) in children with SARS-CoV-2 infection admitted to a paediatric COVID facility in a tertiary care centre. METHODS: Data with respect to clinical, epidemiological profile and causes of death in non-survivors (0-12 yr old) of SARS-CoV-2 infection admitted to a dedicated tertiary care COVID hospital in north India between April 2020 and June 2021 were retrieved and analyzed retrospectively. RESULTS: A total of 475 SARS-CoV-2–positive children were admitted during the study period, of whom 47 died [18 neonates, 14 post-neonatal infants and 15 children (1-12 yr of age)]. The all-cause mortality and COVID-19 death (disease-specific mortality) were 9.9 per cent (47 of 475) and 1.9 per cent (9 of 475), respectively. Underlying comorbidities were present in 35 (74.5%) children, the most common being prematurity and perinatal complications (n=11, 24%) followed by congenital heart disease (n=6, 13%). The common causes of death included septic shock in 10 (21%), COVID pneumonia/severe acute respiratory distress syndrome in nine (19%), neonatal illnesses in eight (17%), primary central nervous system disease in seven (15%) and congenital heart disease with complication in six (13%) children. INTERPRETATION & CONCLUSIONS: Our results showed a high prevalence of underlying comorbidities and a low COVID-19 death (disease-specific mortality). Our findings highlight that mortality due to COVID-19 can be overestimated if COVID-19 death and all-cause mortality in children infected with SARS-CoV-2 are not separated. Standardized recording of cause of death in children with SARS-CoV-2 infection is important.
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spelling pubmed-98071882023-01-03 Mortality audit of COVID-19 infection among children Sharma, Raman Agarwal, Ashish Ranjan, Ankit Jayashree, Muralidharan Kumar, Praveen Indian J Med Res Original Article BACKGROUND & OBJECTIVES: As severe COVID-19 and mortality are not common in children, there is a scarcity of data regarding the cause of mortality in children infected with SARS-CoV-2. This study was aimed to describe the all-cause mortality and COVID-19 death (disease-specific mortality) in children with SARS-CoV-2 infection admitted to a paediatric COVID facility in a tertiary care centre. METHODS: Data with respect to clinical, epidemiological profile and causes of death in non-survivors (0-12 yr old) of SARS-CoV-2 infection admitted to a dedicated tertiary care COVID hospital in north India between April 2020 and June 2021 were retrieved and analyzed retrospectively. RESULTS: A total of 475 SARS-CoV-2–positive children were admitted during the study period, of whom 47 died [18 neonates, 14 post-neonatal infants and 15 children (1-12 yr of age)]. The all-cause mortality and COVID-19 death (disease-specific mortality) were 9.9 per cent (47 of 475) and 1.9 per cent (9 of 475), respectively. Underlying comorbidities were present in 35 (74.5%) children, the most common being prematurity and perinatal complications (n=11, 24%) followed by congenital heart disease (n=6, 13%). The common causes of death included septic shock in 10 (21%), COVID pneumonia/severe acute respiratory distress syndrome in nine (19%), neonatal illnesses in eight (17%), primary central nervous system disease in seven (15%) and congenital heart disease with complication in six (13%) children. INTERPRETATION & CONCLUSIONS: Our results showed a high prevalence of underlying comorbidities and a low COVID-19 death (disease-specific mortality). Our findings highlight that mortality due to COVID-19 can be overestimated if COVID-19 death and all-cause mortality in children infected with SARS-CoV-2 are not separated. Standardized recording of cause of death in children with SARS-CoV-2 infection is important. Wolters Kluwer - Medknow 2022 2022-10-28 /pmc/articles/PMC9807188/ /pubmed/36124499 http://dx.doi.org/10.4103/ijmr.ijmr_2500_21 Text en Copyright: © 2022 Indian Journal of Medical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sharma, Raman
Agarwal, Ashish
Ranjan, Ankit
Jayashree, Muralidharan
Kumar, Praveen
Mortality audit of COVID-19 infection among children
title Mortality audit of COVID-19 infection among children
title_full Mortality audit of COVID-19 infection among children
title_fullStr Mortality audit of COVID-19 infection among children
title_full_unstemmed Mortality audit of COVID-19 infection among children
title_short Mortality audit of COVID-19 infection among children
title_sort mortality audit of covid-19 infection among children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807188/
https://www.ncbi.nlm.nih.gov/pubmed/36124499
http://dx.doi.org/10.4103/ijmr.ijmr_2500_21
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