On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test

Diagnostic tests are important clinical tools. To assess the sensitivity and specificity of a new test, its results should be compared against a gold standard. However, the gold-standard test is not always available. Herein, I show that we can compare the new test against a well-established diagnost...

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Autor principal: Habibzadeh, Farrokh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2022
Materias:
Lessons in Biostatistics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807233/
https://www.ncbi.nlm.nih.gov/pubmed/36627979
http://dx.doi.org/10.11613/BM.2023.010101
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author Habibzadeh, Farrokh
author_facet Habibzadeh, Farrokh
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description Diagnostic tests are important clinical tools. To assess the sensitivity and specificity of a new test, its results should be compared against a gold standard. However, the gold-standard test is not always available. Herein, I show that we can compare the new test against a well-established diagnostic test (not a gold-standard test, but with known sensitivity and specificity) and compute the sensitivity and specificity of the new test if we would have compared it against the gold-standard test. The technique presented is useful for situations where the gold standard is not readily available.
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spelling pubmed-98072332023-01-09 On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test Habibzadeh, Farrokh Biochem Med (Zagreb) Lessons in Biostatistics Diagnostic tests are important clinical tools. To assess the sensitivity and specificity of a new test, its results should be compared against a gold standard. However, the gold-standard test is not always available. Herein, I show that we can compare the new test against a well-established diagnostic test (not a gold-standard test, but with known sensitivity and specificity) and compute the sensitivity and specificity of the new test if we would have compared it against the gold-standard test. The technique presented is useful for situations where the gold standard is not readily available. Croatian Society of Medical Biochemistry and Laboratory Medicine 2022-12-15 2023-02-15 /pmc/articles/PMC9807233/ /pubmed/36627979 http://dx.doi.org/10.11613/BM.2023.010101 Text en Croatian Society of Medical Biochemistry and Laboratory Medicine. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Lessons in Biostatistics
Habibzadeh, Farrokh
On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test
title On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test
title_full On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test
title_fullStr On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test
title_full_unstemmed On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test
title_short On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test
title_sort on determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test
topic Lessons in Biostatistics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807233/
https://www.ncbi.nlm.nih.gov/pubmed/36627979
http://dx.doi.org/10.11613/BM.2023.010101
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